Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation 英文参考文献.docVIP

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Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation 英文参考文献.doc

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Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation 英文参考文献

Cell-TypeIndependentMYCTargetGenesReveala PrimordialSignatureInvolvedinBiomassAccumulation HongkaiJi1*,GeorgeWu1,XiangcanZhan2,AlexandraNolan3,CherylKoh4,AngeloDeMarzo4 ,Hoang MaiDoan3,JinshuiFan3,ChristopherCheadle3,MohammadFallahi5,JohnL.Cleveland5,ChiV.Dang6*, KarenI.Zeller3* 1Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, 2Department of Gynecology and Obstetrics,JohnsHopkinsUniversitySchoolofMedicineandHugoW.MoserResearchInstituteattheKennedyKriegerInstitute,Baltimore,Maryland,UnitedStatesof America, 3Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 4Department of Pathology, Johns HopkinsUniversitySchoolofMedicine,Baltimore,Maryland,UnitedStatesofAmerica,5DepartmentofCancerBiology,TheScrippsResearchInstitute,ScrippsFlorida, Jupiter,Florida,UnitedStatesofAmerica,6AbramsonCancerCenter,UniversityofPennsylvania,Philadelphia,Pennsylvania,UnitedStatesofAmerica Abstract The functions of keyoncogenic transcription factorsindependent of context havenotbeen fullydelineated despiteour richer understanding of the genetic alterations in human cancers. The MYC oncogene, which produces the Myc transcriptionfactor,isfrequentlyalteredinhumancancerandisamajorregulatoryhubformanycancers.Inthisregard,we soughttounraveltheprimordialsignatureofMycfunctionbyusinghigh-throughputgenomicapproachestoidentifythe cell-typeindependentcoreMyctargetgenesignature.UsingamodelofhumanBlymphomacellsbearinginducibleMYC, weidentifiedastringentsetofdirectMyctargetgenesviachromatinimmunoprecipitation(ChIP),globalnuclearrun-on assay,andchangesinmRNAlevels.WealsoidentifieddirectMyctargetsinhumanembryonicstemcells(ESCs).Wefurther documentthataMyccoresignature(MCS)setoftargetgenesissharedinmouseandhumanESCsaswellasinfourother humancancercelltypes.Remarkably,theexpressionoftheMCScorrelateswithMYCexpressioninacell-typeindependent manneracross8,129microarraysamples