Cell-Free Circulating Plasma hTERT mRNA Is a Useful Marker for Prostate Cancer Diagnosis and Is Associated with Poor Prognosis Tumor Characteristics 英文参考文献.docVIP

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Cell-Free Circulating Plasma hTERT mRNA Is a Useful Marker for Prostate Cancer Diagnosis and Is Associated with Poor Prognosis Tumor Characteristics 英文参考文献.doc

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Cell-Free Circulating Plasma hTERT mRNA Is a Useful Marker for Prostate Cancer Diagnosis and Is Associated with Poor Prognosis Tumor Characteristics 英文参考文献

Cell-FreeCirculatingPlasmahTERTmRNAIsaUseful MarkerforProstateCancerDiagnosisandIsAssociated withPoorPrognosisTumorCharacteristics Jose′ A.March-Villalba1,2,Jose′ M.Mart?′nez-Jabaloyas1,2,Mar?′aJ.Herrero3,JoseSantamaria1,2, SalvadorF.Alin?o3,FranciscoDas?′1,4* 1Fundacio′nInvestigacio′nHospitalCl?′nicoUniversitariodeValencia,InstitutodeInvestigacio′nINCLIVA,Valencia,Spain,2UrologyUnite,HospitalCl?′nicoUniversitariode Valencia,Valencia,Spain,3DepartmentofPharmacology,SchoolofMedicine,UniversityofValencia,Valencia,Spain,4DepartmentofPhysiology,SchoolofMedicine, UniversityofValencia,Valencia,Spain Abstract Background:Serumprostate-specificantigen(PSA)isthemostwidelyusedmarkerfordiagnosingprostatecancer(PCa).It lacksspecificityandpredictivevalue,resultingininaccuratediagnosesandovertreatmentofthedisease.Theaimofthis studywastoassesstheusefulnessofplasmatelomerasereversetranscriptase(hTERT)mRNAasadiagnosticandprognostic toolforPCaanditsassociationwithclinicopathologicalparametersoftumors. PrincipalFindings:PlasmahTERTmRNAlevelsweredeterminedbyqRT-PCRin105consecutivepatientswithelevatedPSA levelsandin68healthyvolunteers.Thediagnosticaccuracy,theefficacyasaprognosticfactorofbiochemicalrecurrence and the association with tumor clinicopathological parameters of plasma hTERT mRNA and serum PSA tests were determined using univariate and multivariate analyses. The results show that plasma hTERT mRNA is a non-invasive biomarkerforPCadiagnosisthatshowshighersensitivity(85%vs.83%),specificity(90%vs.47%),positivepredictivevalue (83%vs.56%),andnegativepredictivevalue(92%vs.77%)thanserumPSA.PlasmahTERTmRNAissignificantlyassociated withpoorprognosistumorclinicopathologicalparametersandisasignificantindependentpredictorofPCa(p,0.0001). Univariate analysis identified plasma hTERT mRNA (but not serum PSA) as a significant prognostic factor of biochemical recurrence.PlasmahTERTmRNAKaplan-Meiercurvesconfirmedthesignificantdifferencesbetweengroupsandpatients with higher levels than the cu