Cellularly-Driven Differences in Network Synchronization Propensity Are Differentially Modulated by Firing Frequency 英文参考文献.docVIP

Cellularly-DrivenDifferencesinNetworkSynchronization PropensityAreDifferentiallyModulatedbyFiring Frequency ChristianG.Fink1*,VictoriaBooth2.,MichalZochowski1,3. 1Department of Physics, University of Michigan, Ann Arbor, Michigan, United States of America, 2Departments of Mathematics and Anesthesiology, University of Michigan,AnnArbor,Michigan,UnitedStatesofAmerica,3BiophysicsProgram,UniversityofMichigan,AnnArbor,Michigan,UnitedStatesofAmerica Abstract Spatiotemporal pattern formation in neuronal networks depends on the interplay between cellular and network synchronization properties. The neuronal phase response curve (PRC) is an experimentally obtainable measure that characterizes the cellular response to small perturbations, and can serve as an indicator of cellular propensity for synchronization.TwobroadclassesofPRCshavebeenidentifiedforneurons:TypeI,inwhichsmallexcitatoryperturbations induceonlyadvancesinfiring,andTypeII,inwhichsmallexcitatoryperturbationscaninducebothadvancesanddelaysin firing. Interestingly, neuronal PRCs are usually attenuated with increased spiking frequency, and Type II PRCs typically exhibitagreaterattenuationofthephasedelayregionthanofthephaseadvanceregion.Wefoundthatthisphenomenon arisesfromaninterplaybetweenthetimeconstantsofactiveioniccurrentsandtheinterspikeinterval.Asaresult,excitatory networks consisting of neurons with Type I PRCs responded very differently to frequency modulation compared to excitatorynetworkscomposedofneuronswithTypeIIPRCs.Specifically,increasedfrequencyinducedasharpdecreasein synchronyofnetworksofTypeIIneurons,whilefrequencyincreasesonlyminimallyaffectedsynchronyinnetworksofType Ineurons.Theseresultsaredemonstratedinnetworksinwhichbothtypesofneuronsweremodeledgenericallywiththe Morris-Lecar model, as well as in networks consisting of Hodgkin-Huxley-based model cortical pyramidal cells in which simulated effects of acetylcholine changed PRC type. These results are robust to different network structures, synapt