Cell Membrane Disruption Stimulates NOPKG Signaling and Potentiates Cell Membrane Repair in Neighboring Cells 英文参考文献.docVIP

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Cell Membrane Disruption Stimulates NOPKG Signaling and Potentiates Cell Membrane Repair in Neighboring Cells 英文参考文献.doc

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Cell Membrane Disruption Stimulates NOPKG Signaling and Potentiates Cell Membrane Repair in Neighboring Cells 英文参考文献

CellMembraneDisruptionStimulatesNO/PKGSignaling andPotentiatesCellMembraneRepairinNeighboring Cells TatsuruTogo* DepartmentofAnatomy,St.MariannaUniversitySchoolofMedicine,Kawasaki,Japan Abstract Resealing of a disrupted plasma membrane at the micron-diameter range requires Ca2+-regulated exocytosis. Repeated membranedisruptionsresealmorequicklythantheinitialwound,andthispotentiationofmembraneresealingpersistsfor at least 24hours after the initial wound. Long-term potentiation of membrane resealing requires CREB-dependent gene expression, which is activated by the PKC- and p38 MAPK-dependent pathway in a wounded cell. The present study demonstratesthatmembraneresealingispotentiatedinbothwoundedandneighboringcellsinMDCKcells.Woundingof cellsexpressingCREB133,amutantvariantofCREB,doesnotshowthepotentiatedresponseofcellmembraneresealingin eitherwoundedorneighboringcells.Furthermore,woundingofcellsinducesCREBphosphorylation,notonlyinwounded cells,butalsoinneighboringcells.Inhibitionofthenitricoxide/PKGsignalingpathwaysuppressesCREBphosphorylationin neighboringcells,butnotinwoundedcells.Thepotentiationofmembraneresealinginneighboringcellsissuppressedif thenitricoxide/PKGpathwayisinhibitedduringtheinitialwound.Together,theseresultssuggestthatthenitricoxide/PKG pathway stimulates CREB phosphorylation in neighboring cells so that subsequent cell membrane disruptions of the neighboringcellsresealmorequickly. Citation: Togo T(2012)CellMembrane DisruptionStimulatesNO/PKGSignalingandPotentiatesCellMembrane RepairinNeighboringCells.PLoSONE 7(8): e42885.doi:10.1371/journal.pone.0042885 Editor:PaulMcNeil,MedicalCollegeofGeorgia,UnitedStatesofAmerica ReceivedApril1,2012;AcceptedJuly12,2012;PublishedAugust7,2012 Copyright: ? 2012 Tatsuru Togo. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:Thisst