CD44s and CD44v6 Expression in Head and Neck Epithelia 英文参考文献.docVIP

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CD44s and CD44v6 Expression in Head and Neck Epithelia 英文参考文献.doc

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CD44s and CD44v6 Expression in Head and Neck Epithelia 英文参考文献

CD44sandCD44v6ExpressioninHeadandNeck Epithelia BrigitteMack1,OlivierGires2* 1Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig-Maximilians-University of Munich, Munich, Germany, 2Clinical Cooperation Group Molecular Oncology, Helmholtz-Zentrum Mu¨nchen, German Research Center for Environmental Health, Head and Neck Research Department, Ludwig-Maximilians-UniversityofMunich,Munich,Germany Abstract Background:CD44splicevariantsarelong-knownasbeingassociatedwithcelltransformation.Recently,thestandardform ofCD44(CD44s)wasshowntobepartofthesignatureofcancerstemcells(CSCs)incolon,breast,andinheadandneck squamouscellcarcinomas(HNSCC).ThisissomewhatincontradictiontopreviousreportsontheexpressionofCD44sin HNSCC.TheaimofthepresentstudywastoclarifytheactualpatternofCD44expressioninheadandneckepithelia. Methods: Expression of CD44s and CD44v6 was analysed by immunohistochemistry with specific antibodies in primary head and neck tissues. Scoring of all specimens followed a two-parameters system, which implemented percentages of positivecellsandstainingintensitiesfrom2to+++(score=%6intensity;resultingmax.score300).Inaddition,cellsurface expressionofCD44sandCD44v6wasassessedinlymphocytesandHNSCC. Results:InnormalepitheliaCD44sandCD44v6wereexpressedin60–95%and50–80%ofcellsandyieldedmeanscores withastandarderrorofamean(SEM)of249.5614.5and198611.13,respectively.Inoralleukoplakiaandinmoderately differentiated carcinomas CD44s and CD44v6 levels were slightly increased (278.967.16 and 242611.7; 291.865.88 and 287.366.88). Carcinomas in situ displayed unchanged levels of both proteins whereas poorly differentiated carcinomas consistentlyexpresseddiminishedCD44sandCD44v6levels.LymphocytesandHNSCClinesstronglyexpressedCD44sbut notCD44v6. Conclusion:CD44sandCD44v6expressiondoesnotdistinguishnormalfrombenignormalignantepitheliaoftheheadand neck. CD44s and CD44v6 were abundantly present in the great majority of cells in head and neck tissues, incl