CD8+ DC, but Not CD8？DC, Isolated from BCG-Infected Mice Reduces Pathological Reactions Induced by Mycobacterial Challenge Infection 英文参考文献.docVIP

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CD8+ DC, but Not CD8？DC, Isolated from BCG-Infected Mice Reduces Pathological Reactions Induced by Mycobacterial Challenge Infection 英文参考文献.doc

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CD8DC,butNotCD8？DC,IsolatedfromBCG-InfectedMiceReducesPathologicalReactionsInducedbyMycobacterialChallengeInfection英文参考文献

CD8+DC,butNotCD82DC,IsolatedfromBCG-Infected MiceReducesPathologicalReactionsInducedby MycobacterialChallengeInfection XiaolingGao1,ShuheWang1,YijunFan1,HongBai1,2,JieYang1,XiYang1,2* 1LaboratoryforInfectionandImmunity,DepartmentofMedicalMicrobiology,FacultyofMedicine,UniversityofManitoba,Winnipeg,Manitoba,Canada,2Departmentof Immunology,TianjinMedicalUniversity,Tianjin,People’sRepublicofChina Abstract Background:Tuberculosisisamycobacterialinfectioncausingworldwidepublichealthproblemsbuttheavailablevaccine isfarfromideal.Type-1Tcellimmunityhasbeenshowntobecriticalforhostdefenceagainsttuberculosisinfection,but theroleofdendriticcell(DC)subsetsinpathogenesisofmycobacterialinfectionremainsunclear. Methodology/Principal Findings: We examined the effectiveness of dendritic cell (DC) subsets in BCG-infected mice in generating immune responses beneficial for pathogen clearance and reduction of pathological reactions in the tissues + following challenge infection. Our data showed that only the adoptive transfer of the subset of CD8a DC isolated from infected mice (iCD8 DC) generated significant protection, demonstrated by less mycobacterial growth and pathological + + changesinthelungandlivertissuesiniCD8 DCrecipientsthansham-treatedcontrolmice.Theadoptivetransferofthe CD8a2DC from the infected mice (iCD82 DC) not only failed to reduce bacterial growth, but enhanced inflammation characterizedbydiffuseheavycellularinfiltration.Notably,iCD82DCproducedsignificantlyhigherlevelsofIL-10thaniCD8+ DCandpromotedmoreTh2cytokineresponsesininvitroDC-Tcellco-cultureandinvivoadoptivetransferexperiments. Conclusions/Significance:ThedataindicatethatinvivoBCG-primedCD8+DCisthedominantDCsubsetininducingprotective immunity especially for reducing pathological reactions in infected tissues. The finding has implications for the rational improvementoftheprophylacticandtherapeuticapproachesforcontrollingtuberculosisinfectionandrelateddiseases. Citation:GaoX,WangS,FanY,BaiH,YangJ,etal.(201