CD47Low Status on CD4 Effectors Is Necessary for the ContractionResolution of the Immune Response in Humans and Mice 英文参考文献.docVIP

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CD47Low Status on CD4 Effectors Is Necessary for the ContractionResolution of the Immune Response in Humans and Mice 英文参考文献.doc

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CD47Low Status on CD4 Effectors Is Necessary for the ContractionResolution of the Immune Response in Humans and Mice 英文参考文献

CD47Low StatusonCD4EffectorsIsNecessaryforthe Contraction/ResolutionoftheImmuneResponsein HumansandMice VuQuangVan1,NobuyasuBaba1,ManuelRubio1,KeikoWakahara1,BenoitPanzini2,CaroleRichard3, GenevieveSoucy4,DenisFranchimont5,GenevieveFortin6,AnaCarolinaMartinezTorres7,8,9, LaurianeCabon7,8,9,SantosSusin7,8,9,MarikaSarfati1* 1Immunoregulation Laboratory, Centre Hospitalier de l’Universite′ de Montre′al, Research Center (CRCHUM), Notre-Dame Hospital, Montreal, Quebec, Canada, 2DepartmentofGastroenterology,CentreHospitalierdel’Universite′ deMontre′al (CHUM),Notre-DameHospital,Montreal,Quebec,Canada,3DepartmentofDigestive TractSurgery,CentreHospitalierdel’Universite′ deMontre′al(CHUM),Notre-DameHospital,Montreal,Quebec,Canada,4DepartmentofPathology,CentreHospitalierde l’Universite′ de Montre′al (CHUM), Notre-Dame Hospital, Montreal, Quebec, Canada, 5Department de Gastroenterology, Erasme Hospital, Universite′ Libre de Bruxelles (ULB), Bruxelles, Belgique, 6Research Institute of McGill University Health Centre, McGill University, Montreal, Quebec, Canada, 7INSERM U872, Mort Cellulaire Programme′e et Physiopathologie des Cellules Tumorales, Equipe 19, Centre de Recherche des Cordeliers, Paris, France, 8Universite′ Pierre et Marie Curie-Sorbonne Universite′s, UMRS872,Paris,France,9Universite′ ParisDescartes,Paris,France Abstract HowdoeffectorCD4Tcellsescapecelldeathduringthecontractionoftheimmuneresponse(IR)remainlargelyunknown. CD47, through interactions with thrombospondin-1 (TSP-1) and SIRP-a, is implicated in cell death and phagocytosis of malignant cells. Here, we reported a reduction in SIRP-a-Fc binding to effector memory T cells (TEM) and in vitro TCR- activatedhumanCD4TcellsthatwaslinkedtoTSP-1/CD47-inducedcelldeath.ThereducedSIRP-a-Fcbinding(CD47low status)wasnotdetectedwhenCD4Tcellswerestainedwithtwoanti-CD47mAbs,whichrecognizedistinctepitopes.In contrast,increasedSIRP-a-Fcbinding(CD47highstatus)markedcentralmemoryTcells(TCM)aswellasactivatedCD4Tcells ex