Cell Pattern in Adult Human Corneal Endothelium 英文参考文献.docVIP

CellPatterninAdultHumanCornealEndothelium CarlosH.Wo¨rner1*,AliciaOlgu?′n1,Jose′ L.Ru?′z-Garc?′a2,NuriaGarzo′n-Jime′nez3 1InstitutodeF?′sica,PontificiaUniversidadCato′licadeValpara?′so,Valpara?′so,Chile,2EscuelaUniversitariadeOptica,′ UniversidadComplutensedeMadrid,Madrid,Espana, ? 3InstitutodeOftalmolog?′aAvanzada,Madrid,Espan?a Abstract Areviewofthecurrentdataonthecelldensityofnormaladulthumanendothelialcellswascarriedoutinordertoestablish somecommonparametersappearinginthedifferentconsideredpopulations.Fromtheanalysisofcellgrowthpatterns,itis inferredthatthecellagingrateissimilarforeachofthedifferentconsideredpopulations.Also,themorphology,thecell distribution and the tendency to hexagonallity are studied. The results are consistent with the hypothesis that this phenomenonisanalogouswithcellbehaviorinotherstructuressuchasdryfoamsandgrainsinpolycrystallinematerials. Therefore,itsdrivingforcemaybecontrolledbythesurfacetensionandthemobilityoftheboundaries. Citation:Wo¨rnerCH,Olgu?′nA,Ru?′z-Garc?′aJL,Garzo′n-Jime′nezN(2011)CellPatterninAdultHumanCornealEndothelium.PLoSONE6(5):e19483.doi:10.1371/ journal.pone.0019483 Editor:CheJohnConnon,UniversityofReading,UnitedKingdom ReceivedSeptember8,2010;AcceptedApril7,2011;PublishedMay13,2011 Copyright: ? 2011 Wo¨rner et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:Theseauthorshavenosupportorfundingtoreport. CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist. *E-mail:cworner@ucv.cl Introduction aging behavior is governed by capillary driving forces (surface tension)actingonthecellboundary. Biologicalcellpatternsareacontemporarythemeofstudy,both for its intrinsic biological interest and also by their potential medicalapplications.Currentresearchhasbeenrecentlysumma- rized[1]andlately,itispossiblealsotomentiont