Cell Lineage Analysis of the Mammalian Female Germline 英文参考文献.docVIP

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Cell Lineage Analysis of the Mammalian Female Germline 英文参考文献.doc

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Cell Lineage Analysis of the Mammalian Female Germline 英文参考文献

CellLineageAnalysisoftheMammalianFemale Germline YitzhakReizel1.,ShalevItzkovitz2,3.,RivkaAdar3.,JudithElbaz1,AdrianJinich2,NoaChapal-Ilani2, YosefE.Maruvka2,NavaNevo1,ZiporaMarx3,InnaHorovitz3,AdamWasserstrom3,AviMayo4 ,Irena Shur5,DafnaBenayahu5,KarlSkorecki6,EranSegal2,NavaDekel1*,EhudShapiro2,3* 1DepartmentofBiologicalRegulation,WeizmannInstituteofScience,Rehovot,Israel,2DepartmentofComputerScienceandAppliedMathematics,WeizmannInstitute of Science, Rehovot, Israel, 3Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel, 4Department of Molecular Cell Biology, Weizmann InstituteofScience,Rehovot,Israel,5DepartmentofCellandDevelopmentalBiology,SacklerSchoolofMedicine,Tel-AvivUniversity,Tel-Aviv,Israel,6RappaportFaculty ofMedicineandResearchInstitute,TechnionandRambamMedicalCenter,Haifa,Israel Abstract Fundamental aspects of embryonic and post-natal development, including maintenance of the mammalian female germline,arelargelyunknown.Hereweemployaretrospective,phylogenetic-basedmethodforreconstructingcelllineage treesutilizingsomaticmutationsaccumulatedinmicrosatellites,tostudyfemalegermlinedynamicsinmice.Reconstructed celllineagetreescanbeusedtoestimatelineagerelationshipsbetweendifferentcelltypes,aswellascelldepth(numberof celldivisionssincethezygote).Weshowthat,inthereconstructedmousecelllineagetrees,oocytesformclustersthatare separatefromhematopoieticandmesenchymalstemcells,bothinyoungandoldmice,indicatingthatthesepopulations belongtodistinctlineages.Furthermore,whilecumuluscellssampledfromdifferentovarianfolliclesaredistinctlyclustered onthereconstructedtrees,oocytesfromtheleftandrightovariesarenot,suggestingamixingoftheirprogenitorpools. Wealsoobservedanincreaseinoocytedepthwithmouseage,whichcanbeexplainedeitherbydepth-guidedselectionof oocytes for ovulation or by post-natal renewal. Overall, our study sheds light on substantial novel aspects of female germlinepreservationanddevelopment. Citation: Reizel Y, Itzkovitz S, Adar R, E