Cell Lineage and Regional Identity of Cultured Spinal Cord Neural Stem Cells and Comparison to Brain-Derived Neural Stem Cells 英文参考文献.docVIP

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Cell Lineage and Regional Identity of Cultured Spinal Cord Neural Stem Cells and Comparison to Brain-Derived Neural Stem Cells 英文参考文献.doc

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Cell Lineage and Regional Identity of Cultured Spinal Cord Neural Stem Cells and Comparison to Brain-Derived Neural Stem Cells 英文参考文献

CellLineageandRegionalIdentityofCulturedSpinal CordNeuralStemCellsandComparisontoBrain-Derived NeuralStemCells TheresaK.Kelly1,2,StanislavL.Karsten3,DanielH.Geschwind1,4,5,HarleyI.Kornblum1,2,6 * 1The Semel Institute for Neuroscience and Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America,2MentalRetardationResearchCenter,DavidGeffenSchoolofMedicine,UniversityofCaliforniaLosAngeles,LosAngeles,California,UnitedStatesofAmerica, 3DivisionofNeuroscienceResearch,DepartmentofNeurology,LosAngelesBiomedicalResearchInstituteatHarbor,UniversityofCaliforniaLosAngelesMedicalCenter, Torrance,California,UnitedStatesofAmerica,4PrograminNeurogeneticsandDepartmentofNeurology,DavidGeffenSchoolofMedicine,UniversityofCaliforniaLos Angeles,LosAngeles,California,UnitedStatesofAmerica,5DepartmentofHumanGenetics,DavidGeffenSchoolofMedicine,UniversityofCaliforniaLosAngeles,Los Angeles, California, United States of America, 6Departments of Molecular and Medical Pharmacology, Psychiatry, Pediatrics and Neurology, David Geffen School of Medicine,UniversityofCaliforniaLosAngeles,LosAngeles,California,UnitedStatesofAmerica Abstract Neuralstemcells(NSCs)canbeisolatedfromdifferentregionsofthecentralnervoussystem.Therehasbeencontroversy whether regional differences amongst stem and progenitor cells are cell intrinsic and whether these differences are maintainedduringexpansioninculture.Theidentificationofinherentregionaldifferenceshasimportantimplicationsfor theuseofthesecellsinneuralrepair.Here,wecomparedNSCsderivedfromthespinalcordandembryoniccortex.We found that while cultured cortical and spinal cord derived NSCs respond similarly to mitogens and are equally neuronogenic,theyretainandmaintainthroughmultiplepassagesgeneexpressionpatternsindicativeoftheregionfrom whichtheywereisolated(e.gEmx2andHoxD10).Furthermicroarrayanalysisidentified229genesthatweredifferentially expressed between cortical and spinal cord derived n