CD4+CD25+ Regulatory T Cell Depletion Modulates Anxiety and Depression-Like Behaviors in Mice 英文参考文献.docVIP

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CD4+CD25+ Regulatory T Cell Depletion Modulates Anxiety and Depression-Like Behaviors in Mice 英文参考文献.doc

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CD4CD25RegulatoryTCellDepletionModulatesAnxietyandDepression-LikeBehaviorsinMice英文参考文献

CD4+CD25+RegulatoryTCellDepletionModulates AnxietyandDepression-LikeBehaviorsinMice Soo-JeongKim1,HyojungLee1,GihyunLee1,Sei-JoongOh1,Min-KyuShin1,InsopShim2,HyunsuBae1* 1DepartmentofPhysiology,CollegeofOrientalMedicine,Kyung-HeeUniversity,Seoul,RepublicofKorea,2AcupunctureandMeridianScienceResearchCenter,College ofOrientalMedicine,Kyung-HeeUniversity,Seoul,RepublicofKorea Abstract Stresshasbeenshowntosuppressimmunefunctionandincreasesusceptibilitytoinflammatory diseaseandpsychiatric + + disease.CD4 CD25 regulatoryT(Treg)cellsareprominentinimmuneregulation.Thisstudywasconductedtodetermineif anti-CD25 antibody (Ab) mediated depletion of Treg cells in mice susceptibility to stress-induced development of depression-likebehaviors,aswellasimmunologicalandneurochemicalactivity.Toaccomplishthis,anelevatedplus-maze test (EPM), tail suspension test (TST), and forced swim test (FST) were used to examine depression-like behaviors upon chronicimmobilizationstress.Immuneimbalancestatuswasobservedbasedonanalysisofserumcytokinesusingamouse cytometricbeadarrayinconjunctionwithflowcytometryandchangesinthelevelsofserotonin(5-HT)anddopamine(DA) inthebrainweremeasuredbyhighperformanceliquidchromatography(HPLC).Thetimespentintheopenarmsofthe EPMdecreasedsignificantlyandtheimmobilitytimeintheFSTincreasedsignificantlyintheanti-CD25Ab-treatedgroup when compared with the non stressed wild-type group. In addition, interlukin-6 (IL-6), tumor necrosis factor-a′ (TNF-a′), interlukin-2(IL-2),interferon-gamma(IFN-c),interlukin-4(IL-4)andinterlukin-17A(IL-17A)concentrationsweresignificantly upregulated in the stressed anti-CD25 Ab-treated group when compared with the non stressed wild-type group. Furthermore,thenonstressedanti-CD25Ab-treatedgroupdisplayeddecreased5-HTlevelswithinthehippocampuswhen + + compared with the non stressed wild-type group. These results suggest that CD4 CD25 Treg cell depletion modulated alterations in depressive behavior, cytokine and monoaminergic activity. The