Dextran Sodium Sulfate (DSS) Induces Colitis in Mice by Forming Nano-Lipocomplexes with Medium-Chain-Length Fatty Acids in the Colon 英文参考文献.docVIP

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Dextran Sodium Sulfate (DSS) Induces Colitis in Mice by Forming Nano-Lipocomplexes with Medium-Chain-Length Fatty Acids in the Colon 英文参考文献.doc

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Dextran Sodium Sulfate (DSS) Induces Colitis in Mice by Forming Nano-Lipocomplexes with Medium-Chain-Length Fatty Acids in the Colon 英文参考文献

DextranSodiumSulfate(DSS)InducesColitisinMiceby FormingNano-LipocomplexeswithMedium-Chain- LengthFattyAcidsintheColon HamedLaroui1*,SarahA.Ingersoll1,2,HongChunLiu3,4,MarkT.Baker1,SaravananAyyadurai1,MoizA. Charania1,FaminaLaroui2,YutaoYan1,2,ShanthiV.Sitaraman3,DidierMerlin1,2 1DepartmentofBiology,CenterDiagnosticsandTherapeutics,GeorgiaStateUniversity,Atlanta,Georgia,UnitedStatesofAmerica, 2VeteransAffairsMedicalCenter, Decatur, Georgia, United States of America, 3Department of Medicine, Division of Digestive Diseases, Emory University, Atlanta, Georgia, United States of America, 4DepartmentofGastroenterology,ZhongshanHospital,FudanUniversity,Shanghai,China Abstract Inflammatoryboweldiseases(IBDs),primarilyulcerativecolitisandCrohn’sdisease,areinflammatorydisorderscausedby multiple factors. Research on IBD has often used the dextran sodium sulfate (DSS)-induced colitis mouse model. DSS inducesinvivobutnotinvitrointestinalinflammation.Inaddition,noDSS-associatedmolecule(freeglucose,sodiumsulfate solution, free dextran) induces in vitro or in vivo intestinal inflammation. We find that DSS but not dextran associated moleculesestablishedlinkageswithmedium-chain-lengthfattyacids(MCFAs),suchasdodecanoate,thatarepresentinthe colonic lumen. DSS complexed to MCFAs forms nanometer-sized vesicles ,200nm in diameter that can fuse with colonocyte membranes. The arrival of nanometer-sized DSS/MCFA vesicles in the cytoplasm may activate intestinal inflammatorysignalingpathways.WealsoshowthattheinflammatoryactivityofDSSismediatedbythedextranmoieties. ThedeleteriouseffectofDSSislocalizedprincipallyinthedistalcolon,thereforeitwillbeimportanttochemicallymodify DSStodevelopmaterialsbeneficialtothecolonwithoutaffectingcolon-targetingspecificity. Citation:LarouiH,IngersollSA,LiuHC,BakerMT,AyyaduraiS,etal.(2012)DextranSodiumSulfate(DSS)InducesColitisinMicebyFormingNano-Lipocomplexes withMedium-Chain-LengthFattyAcidsintheColon.PLoSONE7(3):e32084.doi:10.1371/journal.pone.0032084