Diastolic Dysfunction of Aging Is Independent of Myocardial Structure but Associated with Plasma Advanced Glycation End-Product Levels 英文参考文献.docVIP

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Diastolic Dysfunction of Aging Is Independent of Myocardial Structure but Associated with Plasma Advanced Glycation End-Product Levels 英文参考文献.doc

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Diastolic Dysfunction of Aging Is Independent of Myocardial Structure but Associated with Plasma Advanced Glycation End-Product Levels 英文参考文献

DiastolicDysfunctionofAgingIsIndependentof MyocardialStructurebutAssociatedwithPlasma AdvancedGlycationEnd-ProductLevels DuncanJ.Campbell1,2*,JithendraB.Somaratne3,AliciaJ.Jenkins2,DavidL.Prior2,3,MichaelYii4,5 , JamesF.Kenny5,AndrewE.Newcomb4,5,CasperG.Schalkwijk6,MaryJaneBlack7,DarrenJ.Kelly2 1St. Vincent’s Institute of Medical Research, Fitzroy, Australia, 2Department of Medicine, The University of Melbourne, St. Vincent’s Health, Fitzroy, Australia, 3DepartmentofCardiology,St.Vincent’sHealth,Fitzroy,Australia,4DepartmentofSurgery,UniversityofMelbourne,St.Vincent’sHealth,Fitzroy,Australia,5Department ofCardiothoracicSurgery,St.Vincent’sHealth,Fitzroy,Australia,6DepartmentofInternalMedicine,UniversityofMaastricht,Maastricht,TheNetherlands,7Department ofAnatomyandDevelopmentalBiology,MonashUniversity,Clayton,Australia Abstract Background: Heart failure is associated with abnormalities of myocardial structure, and plasma levels of the advanced glycationend-product(AGE)Ne-(carboxymethyl)lysine(CML)correlatewiththeseverityandprognosisofheartfailure.Aging isassociatedwithdiastolicdysfunctionandincreasedriskofheartfailure,andweinvestigatedthehypothesisthatdiastolic dysfunctionofaginghumansisassociatedwithalteredmyocardialstructureandplasmaAGElevels. Methods: We performed histological analysis of non-ischemic left ventricular myocardial biopsies and measured plasma levelsoftheAGEsCMLandlowmolecularweightfluorophores(LMWFs)in26menundergoingcoronaryarterybypassgraft surgerywhohadtransthoracicechocardiographybeforesurgery.Nonehadpreviouscardiacsurgery,myocardialinfarction, atrialfibrillation,orheartfailure. Results:Thepatientswereaged43–78yearsandincreasingagewasassociatedwithechocardiographicindicesofdiastolic dysfunction, with higher mitral Doppler flow velocity A wave (r=0.50, P=0.02), lower mitral E/A wave ratio (r=0.64, P=0.001),longermitralvalvedecelerationtime(r=0.42,P=0.03)andlowerearlydiastolicpeakvelocityofthemitralseptal annulus,e’(r=0.55,P=0.008).However,neith