Differences between Spinocerebellar Ataxias and Multiple System Atrophy-Cerebellar Type on Proton Magnetic Resonance Spectroscopy 英文参考文献.docVIP

下载本文档

3
0
约3.26万字
约 7页
2017-05-11 发布于上海
举报
版权申诉

Differences between Spinocerebellar Ataxias and Multiple System Atrophy-Cerebellar Type on Proton Magnetic Resonance Spectroscopy 英文参考文献.doc

1、本文档共7页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Differences between Spinocerebellar Ataxias and Multiple System Atrophy-Cerebellar Type on Proton Magnetic Resonance Spectroscopy 英文参考文献

DifferencesbetweenSpinocerebellarAtaxiasand MultipleSystemAtrophy-CerebellarTypeonProton MagneticResonanceSpectroscopy Jiing-FengLirng1,2*.,Po-ShanWang3,4.,Hung-ChiehChen1,5*,Bing-WenSoong3,6*,WanYuoGuo1,2 , Hsiu-MeiWu1,2,Cheng-YenChang1,2 1National Yang-Ming University School of Medicine, Taipei, Taiwan, 2Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan, 3Department of Neurology,NationalYang-MingUniversitySchoolofMedicine,Taipei,Taiwan,4DepartmentofMedicine,MunicipalGandauHospital,Taipei,Taiwan,5Departmentof Radiology,TaichungVeteransGeneralHospital,Taipei,Taiwan,6DepartmentofNeurology,TaipeiVeteransGeneralHospital,Taipei,Taiwan Abstract Purpose: A broad spectrum of diseases can manifest cerebellar ataxia. In this study, we investigated whether proton magnetic resonance spectroscopy (MRS) may help differentiate spinocerebellar ataxias (SCA) from multiple systemic atrophy-cerebellartype(MSA-C). Material and Methods: This prospective study recruited 156 patients with ataxia, including spinocerebellar ataxia (SCA) types 1, 2, 3, 6 and 17 (N=94) and MSA-C (N=62), and 44 healthy controls. Single voxel proton MRS in the cerebellar hemispheresandvermisweremeasured.Thedifferenceswereevaluatedusingnonparametricstatistictests. Results: When compared with healthy controls, the cerebellar and vermis NAA/Cr and NAA/Cho were lower in all patients(p,0.002).TheCho/CrwaslowerinSCA2andMSA-C(p,0.0005).TheNAA/CrandCho/CrwerelowerinMSA-Cor SCA2comparingwithSCA3orSCA6.TheMRSfeaturesofSCA1wereinbetween(p,0.018).ThecerebellarNAA/Chowas lowerinSCA2thanSCA1,SCA3orSCA6(p,0.04).ThecerebellarNAA/ChoinMSA-CwaslowerthanSCA3(p,0.0005).Inthe early stages of diseases (SARA score,10), significant lower NAA/Cr and NAA/Cho in SCA2, SCA3, SCA6 or MSA-C were observedcomparingwithhealthycontrols(p,0.017).TheCho/CrwaslowerinMSA-CorSCA2(p,0.0005).Patientswith MSA-CandSCA2hadlowerNAA/CrandCho/CrthanSCA3orSCA6(p,0.016). Conclusion:ByusingMRS,significantlylowerNAA/Cr,Cho/CrandNAA/Ch