Dietary Protein and Blood Pressure A Systematic Review 英文参考文献.docVIP

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Dietary Protein and Blood Pressure A Systematic Review 英文参考文献.doc

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Dietary Protein and Blood Pressure A Systematic Review 英文参考文献

DietaryProteinandBloodPressure:ASystematicReview WiekeAltorf–vanderKuil1,2*,Marie¨lleF.Engberink1,2,ElizabethJ.Brink1,3,MarleenA.vanBaak1,4 , StephanJ.L.Bakker1,5,GerjanNavis1,5,Pietervan’tVeer2,JohannaM.Geleijnse1,2 1Top Institute Food and Nutrition, Wageningen, The Netherlands, 2Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands, 3Human StudiesGroup,TNOQualityofLife,Zeist,TheNetherlands,4DepartmentofHumanBiology,NUTRIMSchoolforNutrition,ToxicologyandMetabolism,FacultyofHealth, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands, 5Kidney Center, University Medical Center Groningen and University of Groningen, Groningen,TheNetherlands Abstract Background: Elevated blood pressure (BP), which is a major risk factor for cardiovascular disease, is highly prevalent worldwide.Recently,interesthasgrownintheroleofdietaryproteininhumanBP.Weperformedasystematicreviewofall publishedscientificliteratureondietaryprotein,includingproteinfromvarioussources,inrelationtohumanBP. Methodology/Principal Findings: We performed a MEDLINE search and a manual search to identify English language studiesontheassociationbetweenproteinandbloodpressure,publishedbeforeJune2010.Atotalof46papersmetthe inclusioncriteria.Mostobservationalstudiesshowednoassociationoraninverseassociationbetweentotaldietaryprotein andBPorincidenthypertension.Resultsofbiomarkerstudiesandrandomizedcontrolledtrialsindicatedabeneficialeffect ofproteinonBP.Thisbeneficialeffectmaybemainlydrivenbyplantprotein,accordingtoresultsinobservationalstudies. Dataonproteinfromspecificsources(e.g.fromfish,dairy,grain,soy,andnut)werescarce.Therewassomeevidencethat BPinpeoplewithelevatedBPand/orolderagecouldbemoresensitivetodietaryprotein. Conclusions/Significance:Inconclusion,evidencesuggestsasmallbeneficialeffectofproteinonBP,especiallyforplant protein.Abloodpressureloweringeffectofproteinmayhaveimportantpublichealthimplications.However,thiswarrants furtherinvestigationinrandomi