Differential Deployment of REST and CoREST Promotes Glial Subtype Specification and Oligodendrocyte Lineage Maturation 英文参考文献.docVIP

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Differential Deployment of REST and CoREST Promotes Glial Subtype Specification and Oligodendrocyte Lineage Maturation 英文参考文献.doc

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Differential Deployment of REST and CoREST Promotes Glial Subtype Specification and Oligodendrocyte Lineage Maturation 英文参考文献

DifferentialDeploymentofRESTandCoRESTPromotes GlialSubtypeSpecificationandOligodendrocyteLineage Maturation JosephJ.Abrajano1,3,9.*,IrfanA.Qureshi1,2,9.*,SolenGokhan1,2,9,DeyouZheng1,2,3,6,9 ,Aviv Bergman3,5,6,7,MarkF.Mehler1,2,3,4,8,9 * 1InstituteforBrainDisordersandNeuralRegeneration,AlbertEinsteinCollegeofMedicine,Bronx,NewYork,UnitedStatesofAmerica,2DepartmentofNeurology,Albert EinsteinCollegeofMedicine,Bronx,NewYork,UnitedStatesofAmerica,3DepartmentofNeuroscience,AlbertEinsteinCollegeofMedicine,Bronx,NewYork,United StatesofAmerica,4DepartmentofPsychiatryandBehavioralSciences,AlbertEinsteinCollegeofMedicine,Bronx,NewYork,UnitedStatesofAmerica,5Departmentof Pathology,AlbertEinsteinCollegeofMedicine,Bronx,NewYork,UnitedStatesofAmerica,6DepartmentofGenetics,AlbertEinsteinCollegeofMedicine,Bronx,New York,UnitedStatesofAmerica,7DepartmentofSystemsandComputationalBiology,AlbertEinsteinCollegeofMedicine,Bronx,NewYork,UnitedStatesofAmerica, 8Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York, United States of America, 9Rose F. Kennedy Center for Research on Intellectual and DevelopmentalDisabilities,AlbertEinsteinCollegeofMedicine,Bronx,NewYork,UnitedStatesofAmerica Abstract Background:Therepressorelement-1(RE1)silencingtranscriptionfactor/neuron-restrictivesilencerfactor(REST/NRSF)isa mastertranscriptionalregulatorthatbindstonumerousgenomicRE1siteswhereitactsasamolecularscaffoldfordynamic recruitment of modulatory and epigenetic cofactors, including corepressor for element-1-silencing transcription factor (CoREST). CoREST also acts as a hub for various cofactors that play important roles in epigenetic remodeling and transcriptionalregulation.WhileRESTcanrecruitCoRESTtoitsmacromolecularcomplex,CoRESTcomplexesalsofunctionat genomicsitesindependentlyofREST.RESTandCoRESTperformabroadarrayofcontext-specificfunctions,whichinclude repressionofneuronaldifferentiationgenesinneuralstemcells(NSCs)andothernon-neuronalcellsaswellaspromotionof neurogenesi