Differential Effects of MYH9 and APOL1 Risk Variants on FRMD3 Association with Diabetic ESRD in African Americans 英文参考文献.docVIP

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Differential Effects of MYH9 and APOL1 Risk Variants on FRMD3 Association with Diabetic ESRD in African Americans 英文参考文献.doc

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Differential Effects of MYH9 and APOL1 Risk Variants on FRMD3 Association with Diabetic ESRD in African Americans 英文参考文献

DifferentialEffectsofMYH9andAPOL1RiskVariantson FRMD3AssociationwithDiabeticESRDinAfrican Americans BarryI.Freedman1.*,CarlD.Langefeld2.*,LingyiLu2,JasminDivers2,MaryE.Comeau2,JeffreyB. Kopp3,CherylA.Winkler4,GeorgeW.Nelson5,RandallC.Johnson5,6,NicholetteD.Palmer7,8,9,PamelaJ. Hicks7,8,9,MeredithA.Bostrom7,8,9,JessicaN.Cooke8,9,10,CaitrinW.McDonough8,9,10,DonaldW. Bowden7,8,9,11 * 1SectiononNephrology,DepartmentofInternalMedicine,WakeForestSchoolofMedicine,Winston-Salem,NorthCarolina,UnitedStatesofAmerica,2Departmentof BiostatisticalSciencesandCenterforPublicHealthGenomics,WakeForestSchoolofMedicine,Winston-Salem,NorthCarolina,UnitedStatesofAmerica,3KidneyDisease Section,NationalInstituteofDiabetesandDigestiveandKidneyDiseases,NationalInstitutesofHealth,Bethesda,Maryland,UnitedStatesofAmerica,4BasicResearch Laboratory,SAIC-Frederick,NationalCancerInstitute,NationalInstitutesofHealth,Frederick,Maryland,UnitedStatesofAmerica,5BSPCCRGeneticsCore,SAIC-Frederick, NationalCancerInstitute,NationalInstitutesofHealth,Frederick,Maryland,UnitedStates ofAmerica, 6ChairedeBioinformatique,Conservatoire NationaldesArtset Metiers,Paris,France,7DepartmentofBiochemistry,WakeForestSchoolofMedicine,Winston-Salem,NorthCarolina,UnitedStatesofAmerica, 8CenterforDiabetes Research,WakeForestSchoolofMedicine,Winston-Salem,NorthCarolina,UnitedStatesofAmerica,9CenterforGenomicsandPersonalizedMedicineResearch,Wake ForestSchoolofMedicine,Winston-Salem,NorthCarolina,UnitedStatesofAmerica,10PrograminMolecularMedicineandTranslationalScience,WakeForestSchoolof Medicine, Winston-Salem, North Carolina, United States of America, 11Section on Endocrinology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem,NorthCarolina,UnitedStatesofAmerica Abstract Singlenucleotidepolymorphisms(SNPs)inMYH9andAPOL1onchromosome22(c22)arepowerfullyassociatedwithnon- diabeticend-stagerenaldisease(ESRD)inAfricanAmericans(AAs).ManyAAsdiagnosedwithtype2diabeticnephropathy (T2DN