Differential Gene Expression from Genome-Wide Microarray Analyses Distinguishes Lohmann Selected Leghorn and Lohmann Brown Layers 英文参考文献.docVIP

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Differential Gene Expression from Genome-Wide Microarray Analyses Distinguishes Lohmann Selected Leghorn and Lohmann Brown Layers 英文参考文献.doc

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Differential Gene Expression from Genome-Wide Microarray Analyses Distinguishes Lohmann Selected Leghorn and Lohmann Brown Layers 英文参考文献

DifferentialGeneExpressionfromGenome-Wide MicroarrayAnalysesDistinguishesLohmannSelected LeghornandLohmannBrownLayers ChristinHabig1,RobertGeffers2,OttmarDistl1* 1Institute for Animal Breeding andGenetics, University of Veterinary Medicine Hannover (Foundation), Hannover, Germany, 2Department ofCell Biology, Helmholtz CentreforInfectionResearch,Braunschweig,Germany Abstract TheLohmannSelectedLeghorn(LSL)andLohmannBrown(LB)layerlineshavebeenselectedforhigheggproductionsince morethan50yearsandbelongtotheworldwideleadingcommerciallayerlines.Theobjectivesofthepresentstudywereto characterizethemolecularprocessesthataredifferentamongthesetwolayerlinesusingwholegenomeRNAexpression profiles. The hens were kept in the newly developed small group housing system Eurovent German with two different groupsizes.Differentialexpressionwasobservedfor6,276microarrayprobes(FDRadjustedP-value,0.05)amongthetwo layerlinesLSLandLB.A2-foldorgreaterchangeingeneexpressionwasidentifiedon151probesets.InLSL,72ofthe151 probe sets were up- and 79 of them were down-regulated. Gene ontology (GO) enrichment analysis accounting for biologicalprocessesevinced18GO-termsforthe72probesetswithhigherexpressioninLSL,especiallythosetakingpartin immunesystemprocessesandmembraneorganization.Atotalof32enrichedGO-termsweredeterminedamongthe79 down-regulated probe sets of LSL. Particularly, these terms included phosphorus metabolic processes and signaling pathways.Inconclusion,thephenotypicdifferencesamongthetwolayerlinesLSLandLBareclearlyreflectedintheirgene expressionprofilesofthecerebrum.Thesenovelfindingsprovidecluesforgenesinvolvedineconomicallyimportantline characteristicsofcommerciallayinghens. Citation:HabigC,GeffersR,DistlO(2012)DifferentialGeneExpressionfromGenome-WideMicroarrayAnalysesDistinguishesLohmannSelectedLeghornand LohmannBrownLayers.PLoSONE7(10):e46787.doi:10.1371/journal.pone.0046787 Editor:IoannisP.Androulakis,RutgersUniversity,UnitedStatesofAmerica ReceivedApril17,2012;AcceptedSeptember6,2