Differentiation between Vergence and Saccadic Functional Activity within the Human Frontal Eye Fields and Midbrain Revealed through fMRI 英文参考文献.docVIP

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Differentiation between Vergence and Saccadic Functional Activity within the Human Frontal Eye Fields and Midbrain Revealed through fMRI 英文参考文献.doc

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Differentiation between Vergence and Saccadic Functional Activity within the Human Frontal Eye Fields and Midbrain Revealed through fMRI 英文参考文献

DifferentiationbetweenVergenceandSaccadic FunctionalActivitywithintheHumanFrontalEyeFields andMidbrainRevealedthroughfMRI YeldaAlkan1,BharatB.Biswal2*,TaraL.Alvarez1* 1DepartmentofBiomedicalEngineering,NewJerseyInstituteofTechnology,Newark,NewJersey,UnitedStatesofAmerica,2DepartmentofRadiology,Universityof MedicineandDentistryofNewJersey,Newark,NewJersey,UnitedStatesofAmerica Abstract Purpose: Eye movement research has traditionally studied solely saccade and/or vergence eye movements by isolating these systems within a laboratory setting. While the neural correlates of saccadic eye movements are established, few studies have quantified the functional activity of vergence eye movements using fMRI. This study mapped the neural substrates of vergence eye movements and compared them to saccades to elucidate the spatial commonality and differentiationbetweenthesesystems. Methodology:Thestimuluswaspresentedinablockdesignwherethe‘off’stimuluswasasustainedfixationandthe‘on’ stimuluswasrandomvergenceorsaccadiceyemovements.Datawerecollectedwitha3Tscanner.Agenerallinearmodel (GLM)wasusedinconjunctionwithclustersizetodeterminesignificantlyactiveregions.Apairedt-testoftheGLMbeta weight coefficients was computed between the saccade and vergence functional activities to test the hypothesis that vergenceandsaccadicstimulationwouldhavespatialdifferentiationinadditiontosharedneuralsubstrates. Results: Segregated functional activation was observed within the frontal eye fields where a portion of the functional activityfromthevergencetaskwaslocatedanteriortothesaccadicfunctionalactivity(z.2.3;p,0.03).Anareawithinthe midbrainwassignificantlycorrelatedwiththeexperimentaldesignforthevergencebutnotthesaccadedataset.Similar functional activation was observed within the following regions of interest: the supplementary eye field, dorsolateral prefrontal cortex, ventral lateral prefrontal cortex, lateral intraparietal area, cuneus, precuneus, anterior and posterior cingulates,andcerebellarv