Diffusion Tensor Imaging and Decision Making in Cocaine Dependence 英文参考文献.docVIP

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Diffusion Tensor Imaging and Decision Making in Cocaine Dependence 英文参考文献.doc

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Diffusion Tensor Imaging and Decision Making in Cocaine Dependence 英文参考文献

DiffusionTensorImagingandDecisionMakingin CocaineDependence ScottD.Lane1,2*,JoelL.Steinberg1,LiangsuoMa1,KhaderM.Hasan2,3,LarryA.Kramer3,EdwardA. Zuniga1,PonnadaA.Narayana2,3,FrederickGerardMoeller1,2 1Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, Texas, United States of America, 2Program in Neuroscience,GraduateSchoolofBiomedicalSciences,UniversityofTexasHealthScienceCenteratHouston,Houston,Texas,UnitedStatesofAmerica,3Departmentof DiagnosticandInterventionalImaging,UniversityofTexasHealthScienceCenteratHouston,Houston,Texas,UnitedStatesofAmerica Abstract Background:Chronicstimulantabuseisassociatedwithbothimpairmentindecisionmakingandstructuralabnormalities inbraingrayandwhitematter.Recentdatasuggestthesestructuralabnormalitiesmayberelatedtofunctionalimpairment inimportantbehavioralprocesses. Methodology/PrincipalFindings:In15cocaine-dependentand18controlsubjects,weexaminedrelationshipsbetween decision-makingperformanceontheIowaGamblingTask(IGT)andwhitematterintegrityasmeasuredbydiffusiontensor imaging (DTI). Whole brain voxelwise analyses showed that, relative to controls, the cocaine group had lower fractional anisotropy(FA)andhighermeanofthesecondandthirdeigenvalues(lH)infrontalandparietalwhitematterregionsand thecorpuscallosum.CocainesubjectsshowedworseperformanceontheIGT,notablyoverthelast40trials.Importantly,FA andlHvaluesintheseregionsshowedasignificantrelationshipwithIGTperformanceonthelast40trials. Conclusions: Compromised white matter integrity in cocaine dependence may be related to functional impairments in decisionmaking. Citation:LaneSD,SteinbergJL,MaL,HasanKM,KramerLA,etal.(2010)DiffusionTensorImagingandDecisionMakinginCocaineDependence.PLoSONE5(7): e11591.doi:10.1371/journal.pone.0011591 Editor:KenjiHashimoto,ChibaUniversityCenterforForensicMentalHealth,Japan ReceivedApril12,2010;AcceptedJune18,2010;PublishedJuly16,2010 Copyright: ? 2010 Lane et al. This is an open-access article