Dissociable Neural Systems for Timing Evidence from Subjects with Basal Ganglia Lesions 英文参考文献.docVIP

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Dissociable Neural Systems for Timing Evidence from Subjects with Basal Ganglia Lesions 英文参考文献.doc

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Dissociable Neural Systems for Timing Evidence from Subjects with Basal Ganglia Lesions 英文参考文献

DissociableNeuralSystemsforTiming:Evidencefrom SubjectswithBasalGangliaLesions H.BranchCoslett*,MartinWiener*,AnjanChatterjee* DepartmentofNeurology,SchoolofMedicine,UniversityofPennsylvania,Philadelphia,Pennsylvania,UnitedStatesofAmerica Abstract Background:Theneuralbasisoftimingremainspoorlyunderstood.Althoughcontroversypersists,manylinesofevidence, includingstudiesinanimals,functionalimagingstudiesinhumansandlesionstudiesinhumansandanimalssuggestthat thebasalgangliaareimportantfortemporalprocessing[1]. Methodology/Principal Findings: We report data from a wide range of timing tasks from two subjects with disabling neurologic deficits caused by bilateral lesions of the basal ganglia. Both subjects perform well on tasks assessing time estimation, reproduction and production tasks. Additionally, one subject performed normally on psychophysical tasks requiringthecomparisonoftimeintervalsrangingfrommillisecondstoseconds;thesecondsubjectperformedabnormally onthepsychophysicaltaskwitha300msstandardbutdidwellwith600ms,2000msand8000msstandards.Bothsubjects performedpoorlyonanisochronousrhythmproductiontaskonwhichtheyarerequiredtomaintainrhythmictapping. Conclusions/Significance:Asstudiesofsubjectswithbrainlesionspermitstronginferencesregardingthenecessityofbrain structures,thesedatademonstratethatthebasalgangliaarenotcrucialformanysub-orsupra-secondtimingoperationsin humansbutareneededforthetimingproceduresthatunderlietheproductionofmovements.Thisdissociationsuggests thatdistinctanddissociableprocessesmaybeemployedtomeasuretimeintervals.Inconsistenciesinfindingsregarding theneuralbasisoftimingmayreflecttheavailabilityofmultipletemporalprocessingroutinesthatareflexiblyimplemented inresponsetotaskdemands. Citation:CoslettHB,WienerM,ChatterjeeA(2010)DissociableNeuralSystemsforTiming:EvidencefromSubjectswithBasalGangliaLesions.PLoSONE5(4): e10324.doi:10.1371/journal.pone.0010324 Editor:FabienTell,TheResearchCenterofNeurobiology-NeurophysiologyofMarseille,France ReceivedFebr