Distinct Roles of Bcl-2 and Bcl-Xl in the Apoptosis of Human Bone Marrow Mesenchymal Stem Cells during Differentiation 英文参考文献.docVIP

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Distinct Roles of Bcl-2 and Bcl-Xl in the Apoptosis of Human Bone Marrow Mesenchymal Stem Cells during Differentiation 英文参考文献.doc

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Distinct Roles of Bcl-2 and Bcl-Xl in the Apoptosis of Human Bone Marrow Mesenchymal Stem Cells during Differentiation 英文参考文献

DistinctRolesofBcl-2andBcl-XlintheApoptosisof HumanBoneMarrowMesenchymalStemCellsduring Differentiation LisaOliver1,2,ErikaHue1,2,JulienRossignol2,3,GwenolaBougras1,2,PhilippeHulin4 ,Philippe Naveilhan2,3,DominiqueHeymann2,5,LaurentLescaudron2,3,6,Franc?oisM.Vallette1,2 * 1INSERM,UMR892,E′quipeLabellise′e?LiguecontreleCancer?,Nantes,France,2Faculte′deMe′decine,Universite′deNantes,Nantes,France,3INSERM,UMR643,Nantes, France, 4Cellular and Tissular Imaging Core Facility (MicroPICell), Universite′ de Nantes, Nantes, France, 5INSERM, UMR 957, Nantes, France, 6Service de Physiologie AnimaleetHumaine,UFRSciencesetTechniques,Universite′ deNantes,Nantes,France Abstract Background:Adultmesenchymalstemcells(MSCs)canbemaintainedoverextendedperiodsoftimebeforeactivationand differentiation.Littleisknownabouttheprogramsthatsustainthesurvivalofthesecells. Principal Findings: Undifferentiated adult humanMSCs (hMSCs)did notundergo apoptosis in responseto different cell deathinducers.Conversely,thesameinducerscanreadilyinduceapoptosiswhenhMSCsareengagedintheearlystagesof differentiation.ThesurvivalofundifferentiatedcellsislinkedtotheexpressionofBcl-XlandBcl-2incompletelyopposite ways. Bcl-Xl is expressed at similar levels in undifferentiated and differentiated hMSCs while Bcl-2 is expressed only in differentiatedcells.InundifferentiatedhMSCs,thedown-regulationofBcl-Xlisassociatedwithanincreasedsensitivityto apoptosiswhiletheectopicexpressionofBcl-2inducedapoptosis.Thisapoptosisislinkedtothepresenceofcytoplasmic Nur77inundifferentiatedhMSCs. Significance:InhMSCs,theexpressionofBcl-2dependsoncellulardifferentiationandcanbeeitherpro-oranti-apoptotic. Bcl-Xl,ontheotherhand,exhibitsananti-apoptoticactivityunderallconditions. Citation:OliverL,HueE,RossignolJ,BougrasG,HulinP,etal.(2011)DistinctRolesofBcl-2andBcl-XlintheApoptosisofHumanBoneMarrowMesenchymal StemCellsduringDifferentiation.PLoSONE6(5):e19820.doi:10.1371/journal.pone.0019820 Editor:AnnaCarlaGoldberg,AlbertEinsteinInstitut