Drosophila Hox and Sex-Determination Genes Control Segment Elimination through EGFR and extramacrochetae Activity 英文参考文献.docVIP

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Drosophila Hox and Sex-Determination Genes Control Segment Elimination through EGFR and extramacrochetae Activity 英文参考文献.doc

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Drosophila Hox and Sex-Determination Genes Control Segment Elimination through EGFR and extramacrochetae Activity 英文参考文献

DrosophilaHoxandSex-DeterminationGenesControl SegmentEliminationthroughEGFRand extramacrochetaeActivity DavidForonda¤,PalomaMart?′n,ErnestoSa′nchez-Herrero* CentrodeBiolog?′aMolecularSeveroOchoa(C.S.I.C.-U.A.M.),UniversidadAuto′nomadeMadrid,Cantoblanco,Madrid,Spain Abstract The formation or suppression of particular structures is a major change occurring in development and evolution. One exampleofsuchchangeistheabsenceoftheseventhabdominalsegment(A7)inDrosophilamales.Weshowherethat thereisadown-regulationofEGFRactivityandfewerhistoblastsinthemaleA7inearlypupae.Ifthisactivityiselevated,cell numberincreasesandasmallsegmentdevelopsintheadult.Atlaterpupalstages,theremainingprecursorsoftheA7are extruded under the epithelium. This extrusion requires the up-regulation of the HLH protein Extramacrochetae and correlateswithhighlevelsofspaghetti-squash,thegeneencodingtheregulatorylightchainofthenon-musclemyosinII. TheHoxgeneAbdominal-Bcontrolsboththedown-regulationofspitz,aligandoftheEGFRpathway,andtheup-regulation of extramacrochetae, and also regulates the transcription of the sex-determining gene doublesex. The male Doublesex protein, in turn, controls extramacrochetae and spaghetti-squash expression. In females, the EGFR pathway is also down- regulated in the A7 but extramacrochetae and spaghetti-squash are not up-regulated and extrusion of precursor cells is almost absent. Our results show the complex orchestration of cellular and genetic events that lead to this important sexuallydimorphiccharacterchange. Citation: Foronda D, Mart?′n P, Sa′nchez-Herrero E (2012) Drosophila Hox and Sex-Determination Genes Control Segment Elimination through EGFR and extramacrochetaeActivity.PLoSGenet8(8):e1002874.doi:10.1371/journal.pgen.1002874 Editor:EricRulifson,UniversityofCaliforniaSanFrancisco,UnitedStatesofAmerica ReceivedApril12,2012;AcceptedJune18,2012;PublishedAugust9,2012 Copyright: ? 2012 Foronda et al. This is an open-access article distributed under the terms of the Creat