Dual-Phase PET-CT to Differentiate [18F]Fluoromethylcholine Uptake in Reactive and Malignant Lymph Nodes in Patients with Prostate Cancer 英文参考文献.docVIP

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Dual-Phase PET-CT to Differentiate [18F]Fluoromethylcholine Uptake in Reactive and Malignant Lymph Nodes in Patients with Prostate Cancer 英文参考文献.doc

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Dual-Phase PET-CT to Differentiate [18F]Fluoromethylcholine Uptake in Reactive and Malignant Lymph Nodes in Patients with Prostate Cancer 英文参考文献

Dual-PhasePET-CTtoDifferentiate [18F]FluoromethylcholineUptakeinReactiveand MalignantLymphNodesinPatientswithProstateCancer DanielaE.Oprea-Lager1*,AndrewD.Vincent2,ReindertJ.A.vanMoorselaar3,WinaldR.Gerritsen4,5, AlfonsJ.M.vandenEertwegh5,JonasEriksson1,6,RonaldBoellaard1,OttoS.Hoekstra1 1DepartmentofNuclearMedicineandPETResearch,VUUniversityMedicalCenter,Amsterdam,TheNetherlands,2DepartmentofBiometrics,AntonivanLeeuwenhoek Hospital, The Netherlands Cancer Institute, Amsterdam, The Netherlands, 3Department of Urology, VU University Medical Center, Amsterdam, The Netherlands, 4DepartmentofOncology,StRadboudUniversityMedicalCenter,Nijmegen,TheNetherlands,5DepartmentofOncology,VUUniversityMedicalCenter,Amsterdam,The Netherlands,6DepartmentofMedicinalChemistry,OrganicPharmaceuticalChemistry,UppsalaUniversity,Uppsala,Sweden Abstract Purpose: To investigate whether time-trends of enhanced [18F]Fluoromethylcholine ([18F]FCH) in lymph nodes (LN) of prostate cancer (PCa) patients can help to discriminate reactive from malignant ones, and whether single time point standardizeduptakevalue(SUV)measurementsalsosuffice. Procedures: 25 PCa patients with inguinal (presumed benign) and enlarged pelvic LN (presumed malignant) showing enhanced[18F]FCHuptakeatdual-phasePET-CTwereanalyzed.AssociationsbetweenLNstatus(benignversusmalignant) andSUVmaxandSUVmeanA50,determinedat2min(early)and30min(late)postinjection,wereassessed.Weconsideredtwo time-trendsof[18F]FCHuptake:typeA(SUVearly.SUVlate)andtypeB(SUVlate$SUVearly).Histopathologyand/or follow-up were used to confirm the assumption that LN with type A pattern are benign, and LN with type B pattern malignant. Results:Analysisof54nodesshowedthatLNstatus,time-trends,and‘late’(30minp.i.)SUVmaxandSUVmeanA50 parameters werestronglyassociated(P,0.0001).SUVmax relativedifferencewasthebestLNstatuspredictor.AllbutoneinguinalLN showedadecreasing[18F]FCHuptakeovertime(patternA),while95%ofthepelvicnodespresentedastableorincreasing uptake(pattern