Early Colonization with a Group of Lactobacilli Decreases the Risk for Allergy at Five Years of Age Despite Allergic Heredity 英文参考文献.docVIP

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Early Colonization with a Group of Lactobacilli Decreases the Risk for Allergy at Five Years of Age Despite Allergic Heredity 英文参考文献.doc

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Early Colonization with a Group of Lactobacilli Decreases the Risk for Allergy at Five Years of Age Despite Allergic Heredity 英文参考文献

EarlyColonizationwithaGroupofLactobacilliDecreases theRiskforAllergyatFiveYearsofAgeDespiteAllergic Heredity MariaA.Johansson1*,YlvaM.Sjo¨gren1,Jan-OlovPersson2,CarolineNilsson3, EvaSverremark-Ekstro¨m1* 1Arrhenius Laboratories for Natural Sciences, Department of Immunology, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden, 2Division of Mathematical Statistics, Department of Mathematics, Stockholm University, Stockholm, Sweden, 3Department of Clinical Science and Education, So¨dersjukhuset, KarolinskaInstitutetandSachs’ChildrensHospital,Stockholm,Sweden Abstract Background:Microbialdeprivationearlyinlifecanpotentiallyinfluenceimmunemediateddiseasedevelopmentsuchas allergy. The aims of this study were to investigate the influence of parental allergy on the infant gut colonization and associationsbetweeninfantgutmicrobiotaandallergicdiseaseatfiveyearsofage. MethodsandFindings:Fecalsampleswerecollectedfrom58infants,withallergicornon-allergicparentsrespectively,at oneandtwoweeksaswellasatone,twoandtwelvemonthsoflife.DNAwasextractedfromthefecalsamplesandReal time PCR, using species-specific primers, was used for detection of Bifidobacterium (B.) adolescentis, B. breve, B. bifidum, Clostridium (C.) difficile, a group of Lactobacilli (Lactobacillus (L.) casei, L. paracasei and L. rhamnosus) as well as Staphylococcus (S.)aureus. Infants withnon-allergic parents were morefrequently colonized by Lactobacilli compared to infantswithallergicparents(p=0.014).However,non-allergicfive-yearoldsacquiredLactobacillimorefrequentlyduring theirfirstweeksoflife,thantheirallergiccounterparts,irrespectivelyofparentalallergy(p=0.009,p=0.028).Furtherthe non-allergicchildrenwerecolonizedwithLactobacillionmoreoccasionsduringthefirsttwomonthsoflife(p=0.038).Also, significantlymorenon-allergicchildrenwerecolonizedwithB.bifidumatoneweekofagethanthechildrenallergicatfive years(p=0.048). Conclusion:Inthisstudyweshowthatheredityforallergyhasanimpactonthegutmicrobiotaininfantsbuta