Early Detection of Response to Experimental Chemotherapeutic Top216 with [18F]FLT and [18F]FDG PET in Human Ovary Cancer Xenografts in Mice 英文参考文献.docVIP

下载本文档

3
0
约3.72万字
约 9页
2017-05-11 发布于上海
举报
版权申诉

Early Detection of Response to Experimental Chemotherapeutic Top216 with [18F]FLT and [18F]FDG PET in Human Ovary Cancer Xenografts in Mice 英文参考文献.doc

1、本文档共9页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Early Detection of Response to Experimental Chemotherapeutic Top216 with [18F]FLT and [18F]FDG PET in Human Ovary Cancer Xenografts in Mice 英文参考文献

EarlyDetectionofResponsetoExperimental ChemotherapeuticTop216with[18F]FLTand[18F]FDG PETinHumanOvaryCancerXenograftsinMice MetteMunkJensen1,2*,KamilleDumongErichsen3,FredrikBjo¨rkling3,JacobMadsen2,PeterBuhl Jensen3,LiselotteH?jgaard1,2,MaxwellSehested3,AndreasKj?r1,2 1ClusterforMolecularImaging,FacultyofHealthSciences,UniversityofCopenhagen,Copenhagen,Denmark,2DepartmentofClinicalPhysiology,NuclearMedicine PET,Rigshospitalet,Copenhagen,Denmark,3TopotargetA/S,Copenhagen,Denmark Abstract Background:39-deoxy-39-[18F]fluorothymidine(18F-FLT)isatracerusedtoassesscellproliferationinvivo.Theaimofthe study was to use 18F-FLT positron emission tomography (PET) to study treatment responses to a new anti-cancer compound.Todoso,westudiedearlyanti-proliferativeeffectsoftheexperimentalchemotherapyTop216non-invasivelyby PET. Methodology/PrincipalFindings:Invivouptakeof 18F-FLTinhumanovarycancerxenograftsinmice(A2780)wasstudied atvarioustimepointsafterTop216treatment(50mg/kgi.v.at0and48hours)wasinitiated.Baseline 18F-FLTscanswere madebeforeeitherTop216(n=7–10)orvehicle(n=5–7)wasinjectedandrepeatedafter2and6hoursand1and5daysof treatment.Aparallelstudywasmadewith29-deoxy-29-[18F]fluoro-D-glucose(18F-FDG)(n=8).Traceruptakewasquantified usingsmallanimalPET/CT.Imagingresultswerevalidatedbytumorvolumechangesandgene-expressionofKi67andTK1. Top216(50mg/kg0and48hours)inhibitedthegrowthoftheA2780tumorcomparedtothecontrolgroup(P,0.001).18 F- FLTuptakedecreasedsignificantlyat2hours(252%;P,0.001),6hours(249%;P=0.002)andDay1(247%;P,0.001)after Top216 treatment. At Day 5 18F-FLT uptake was comparable to uptake in the control group. Uptake of 18F-FLT was unchanged in the control group during the experiment. In the treatment group, uptake of 18F-FDG was significantly decreasedat6hours(221%;P=0.003),Day1(229%;P,0.001)andDay5(219%;P=0.05)comparedtobaseline. Conclusions/Significance:OneinjectionwithTop216initiatedafastandsignificantdecreaseincell-proliferationassessable by 18F-FLTaft