Dynamics of Antibiotic Resistant Mycobacterium tuberculosis during Long-Term Infection and Antibiotic Treatment 英文参考文献.docVIP

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Dynamics of Antibiotic Resistant Mycobacterium tuberculosis during Long-Term Infection and Antibiotic Treatment 英文参考文献.doc

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Dynamics of Antibiotic Resistant Mycobacterium tuberculosis during Long-Term Infection and Antibiotic Treatment 英文参考文献

DynamicsofAntibioticResistantMycobacterium tuberculosisduringLong-TermInfectionandAntibiotic Treatment SolomonH.Mariam1,2,JimWerngren1,JoakimAronsson3,SvenHoffner1,DanI.Andersson3,4* 1SwedishInstituteforInfectiousDiseaseControl,Solna,Sweden,2AkliluLemmaInstituteofPathobiology,AddisAbabaUniversity,AddisAbaba,Ethiopia,3Department ofInfectiousDiseases,CountyHospitalRyhov,Jo¨nko¨ping,Sweden,4DepartmentofMedicalBiochemistryandMicrobiology,UppsalaUniversity,Uppsala,Sweden Abstract For an infecting bacterium the human body provides several potential ecological niches with both internally (e.g. host immunity)andexternally(e.g.antibioticuse)imposedgrowthrestrictionsthatareexpectedtodriveadaptiveevolutionin thebacterium,includingthedevelopmentofantibioticresistance.Todeterminetheextentandpatternofheterogeneity generatedinabacterialpopulationduringlong-termantibiotictreatment,weexaminedinamonoclonalMycobacterium tuberculosisinfectionantibioticresistantmutantsisolatedfromonepatientduringa9-yearsperiod.Therewasaprogressive accumulationofresistancemutationsintheinfectingclone.Furthermore,apparentclonalsweepsaswellasco-existenceof differentresistantmutantswereobservedduringthistime,demonstratingthatduringtreatmentthereisahighdegreeof dynamics in the bacterial population. These findings have important implications for diagnostics and treatment of drug resistanttuberculosisinfections. Citation: MariamSH,WerngrenJ,AronssonJ,HoffnerS,AnderssonDI(2011)DynamicsofAntibioticResistant MycobacteriumtuberculosisduringLong-Term InfectionandAntibioticTreatment.PLoSONE6(6):e21147.doi:10.1371/journal.pone.0021147 Editor:SebastienGagneux,SwissTropicalandPublicHealthInstitute,Switzerland ReceivedJanuary20,2011;AcceptedMay20,2011;PublishedJune16,2011 Copyright: ? 2011 Mariam et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourceare