Dual Targeted Mitochondrial Proteins Are Characterized by Lower MTS Parameters and Total Net Charge 英文参考文献.docVIP

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Dual Targeted Mitochondrial Proteins Are Characterized by Lower MTS Parameters and Total Net Charge 英文参考文献.doc

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Dual Targeted Mitochondrial Proteins Are Characterized by Lower MTS Parameters and Total Net Charge 英文参考文献

DualTargetedMitochondrialProteinsAreCharacterized byLowerMTSParametersandTotalNetCharge MayaDinur-Mills.,MeravTal.,OphryPines* DepartmentofMolecularBiology,HebrewUniversityMedicalSchool,Jerusalem,Israel Abstract Background: In eukaryotic cells, identical proteins can be located in different subcellular compartments (termed dual- targetedproteins). Methodology/PrincipalFindings:Wedividedareferencesetofmitochondrialproteins(publishedsinglegenestudies)into twogroups:i)Dualtargetedmitochondrialproteinsandii)Exclusivemitochondrialproteins.Mitochondrialproteinswere considereddual-targetediftheywerealsofoundorpredictedtobelocalizedtothecytosol,thenucleus,theendoplasmic reticulum (ER) or the peroxisome. We found that dual localized mitochondrial proteins have i) A weaker mitochondrial targetingsequence(MitoProtIIscore,hydrophobicmomentandnumberofbasicresidues)andii)alowerwhole-proteinnet charge,whencomparedtoexclusivemitochondrialproteins.Wehavealsogeneratedanannotationlistofdual-targeted proteins within the predicted yeast mitochondrial proteome. This considerably large group of dual-localized proteins comprises approximately one quarter of the predicted mitochondrial proteome. We supported this prediction by experimentalverificationofasubgroupofthepredicteddualtargetedproteins. Conclusions/Significance:Takentogether,theseresultsestablishdualtargetingasawidelyabundantphenomenonthat should affect our concepts of gene expression and protein function. Possible relationships between the MTS/mature sequencetraitsandproteindualtargetingarediscussed. Citation:Dinur-MillsM,TalM,PinesO(2008)DualTargetedMitochondrialProteinsAreCharacterizedbyLowerMTSParametersandTotalNetCharge.PLoS ONE3(5):e2161.doi:10.1371/journal.pone.0002161 Editor:RichardR.Copley,WellcomeTrustCentreforHumanGenetics,UnitedKingdom ReceivedJanuary8,2008;AcceptedMarch20,2008;PublishedMay14,2008 Copyright: ?2008 Dinur-Millset al. This isanopen-access article distributed under the terms ofthe CreativeCommons Attribu