Early Environment and Neurobehavioral Development Predict Adult Temperament Clusters 英文参考文献.docVIP
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Early Environment and Neurobehavioral Development Predict Adult Temperament Clusters 英文参考文献
EarlyEnvironmentandNeurobehavioralDevelopment
PredictAdultTemperamentClusters
ElizaCongdon1*,SusanService1,JaanaWessman2,3,JouniK.Seppa¨nen2,4,StefanScho¨nauer2,
JoukoMiettunen5,HannuTurunen3,MarkkuKoiranen6,MattiJoukamaa7,Marjo-RiittaJa¨rvelin6,8,9,10,
LeenaPeltonen3,11,12{,JuhaVeijola4,HeikkiMannila2,4,TiinaPaunio3,5,NelsonB.Freimer1
1UniversityofCaliforniaLosAngelesCenterforNeurobehavioralGenetics,SemelInstituteforNeuroscienceandHumanBehavior,UniversityofCaliforniaLosAngeles,Los
Angeles, California, United States of America, 2Helsinki Institute for Information Technology and Department of Computer Science, University of Helsinki, Helsinki,
Finland,3InstituteforMolecularMedicineFinlandandNationalInstitute forHealthandWelfare,Helsinki,Finland, 4HelsinkiInstitute forInformationTechnologyand
AaltoUniversity,Espoo,Finland,5DepartmentofPsychiatry,UniversityofOuluandOuluUniversityHospital,Oulu,Finland,6InstituteofHealthSciences,Universityof
Oulu,Oulu,Finland,7TampereSchoolofPublicHealth,UniversityofTampere,andPsychiatricDepartment,TampereUniversityHospital,Tampere,Finland,8Department
ofEpidemiologyandBiostatistics,SchoolofPublicHealth,ImperialCollege,FacultyofMedicine,London,UnitedKingdom,9BiocenterOulu,UniversityofOulu,Oulu,
Finland,10NationalInstituteofHealthandWelfare,Oulu,Finland,11WellcomeTrustSangerInstitute,Hinxton,Cambridge,UnitedKingdom,12DepartmentofMedical
Genetics,UniversityofHelsinki,Helsinki,Finland
Abstract
Background: Investigation of the environmental influences on human behavioral phenotypes is important for our
understandingofthecausationofpsychiatricdisorders.However,therearecomplexitiesassociatedwiththeassessmentof
environmentalinfluencesonbehavior.
Methods/Principal Findings: We conducted a series of analyses using a prospective, longitudinal study of a nationally
representative birth cohort from Finland (the Northern Finland 1966 Birth Cohort). Participants included a total of 3,761
maleandfemalecohortmemberswhowerelivinginFinlandattheag
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