Early Endocardial Morphogenesis Requires SclTal1 英文参考文献.docVIP

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Early Endocardial Morphogenesis Requires SclTal1 英文参考文献.doc

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Early Endocardial Morphogenesis Requires SclTal1 英文参考文献

EarlyEndocardialMorphogenesis RequiresScl/Tal1 Jeroen Bussmann1,Jeroen Bakkers1,2,Stefan Schulte-Merker1* 1HubrechtInstitute,Utrecht,TheNetherlands,2InteruniversityCardiologyInstituteoftheNetherlands,Utrecht,TheNetherlands Theprimitivehearttubeiscomposedofanoutermyocardialandaninnerendocardiallayerthatwillgiverisetothe cardiac valves and septa. Specification and differentiation of these two cell layers are among the earliest events in heartdevelopment,buttheembryonicoriginsandgeneticregulationofearlyendocardialdevelopmentremainlargely undefined. We have analyzed early endocardial development in the zebrafish using time-lapse confocal microscopy andshowthattheendocardiumseemstooriginatefromaregioninthelateralplatemesodermthatwillgiveriseto hematopoieticcellsoftheprimitivemyeloidlineage.Endocardialprecursorsappeartorapidlymigratetothesiteof heart tube formation, where they arrive prior to the bilateral myocardial primordia. Analysis of a newly discovered zebrafishScl/Tal1mutantshowedanadditionalandpreviouslyundescribedroleofthistranscriptionfactorduringthe developmentoftheendocardium.InScl/Tal1mutantembryos,endocardialprecursorsarespecified,butmigrationis severelydefectiveandendocardialcellsaggregateattheventricularpoleoftheheart.Wefurthershowthattheinitial fusionofthebilateralmyocardialprecursorpopulationsoccursindependentlyoftheendocardiumandtal1function. Our results suggest early separation of the two components of the primitive heart tube and imply Scl/Tal1 as an indispensablecomponentofthemolecularhierarchythatcontrolsendocardiummorphogenesis. Citation:BussmannJ,BakkersJ,Schulte-MerkerS(2007)EarlyendocardialmorphogenesisrequiresScl/Tal1.PLoSGenet3(8):e140.doi:10.1371/journal.pgen.0030140 scription factor nkx2.5, expression of which is detected in the zebra?sh in bilateral populations starting at the ten- Introduction Theprimitivehearttubeisthe?rstfunctionalorganinthe vertebrate embryo and is composed of a myocardial tube lined by an inner endothelial layer call