Economic Impact of Dengue Illness and the Cost-Effectiveness of Future Vaccination Programs in Singapore 英文参考文献.docVIP

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Economic Impact of Dengue Illness and the Cost-Effectiveness of Future Vaccination Programs in Singapore 英文参考文献.doc

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Economic Impact of Dengue Illness and the Cost-Effectiveness of Future Vaccination Programs in Singapore 英文参考文献

EconomicImpactofDengueIllnessandthe Cost-EffectivenessofFutureVaccinationPrograms inSingapore LuisR.Carrasco1,LindaK.Lee2,VernonJ.Lee3,4,5,EngEongOoi6,DonaldS.Shepard7,TunL.Thein2, VictorGan2,AlexR.Cook1,3,8*,DavidLye2,9,LeeChingNg10,YeeSinLeo2,9 1Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore, 2Communicable Disease Centre, Tan Tock Seng Hospital, Singapore, Singapore, 3Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, 4Biodefence Centre, Ministry of Defence, Singapore,Singapore,5CentreforHealthServicesResearch,NationalUniversityofSingapore,Singapore,Singapore,6PrograminEmergingInfectiousDiseases,Duke- NUSGraduateMedicalSchool,Singapore,Singapore,7BrandeisUniversity,Waltham,Massachusetts,UnitedStatesofAmerica,8PrograminHealthServicesandSystems Research, Duke-NUS Graduate Medical School, Singapore, Singapore, 9Department of Medicine, School of Medicine, National University of Singapore, Singapore, Singapore,10EnvironmentalHealthInstitute,NationalEnvironmentAgency,Singapore,Singapore Abstract Background:Dengueillnesscauses50–100millioninfectionsworldwideandthreatens2.5billionpeopleinthetropicaland subtropicalregions.Littleisknownaboutthediseaseburdenandeconomicimpactofdengueinhigherresourcedcountries orthecost-effectivenessofpotentialdenguevaccinesinsuchsettings. Methods and Findings: Weestimate thedirect and indirectcosts of denguefrom hospitalized andambulatory cases in Singapore. We consider inter alia the impacts of dengue on theeconomy using the human-capital and the friction cost methods.Diseaseburdenwasestimatedusingdisability-adjustedlifeyears(DALYs)andthecost-effectivenessofapotential vaccine program was evaluated. The average economic impact of dengue illness in Singapore from 2000 to 2009 in constant 2010 US$ ranged between $0.85 billion and $1.15 billion, of which control costs constitute 42%–59%. Using empirically derived disability weights, we estimat