Effectiveness of the AS03-Adjuvanted Vaccine against Pandemic Influenza Virus A(H1N1) 2009 – A Comparison of Two Methods; Germany, 200910 英文参考文献.docVIP

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Effectiveness of the AS03-Adjuvanted Vaccine against Pandemic Influenza Virus A(H1N1) 2009 – A Comparison of Two Methods; Germany, 200910 英文参考文献.doc

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Effectiveness of the AS03-Adjuvanted Vaccine against Pandemic Influenza Virus A(H1N1) 2009 – A Comparison of Two Methods; Germany, 200910 英文参考文献

EffectivenessoftheAS03-AdjuvantedVaccineagainst PandemicInfluenzaVirusA/(H1N1)2009–AComparison ofTwoMethods;Germany,2009/10 HelmutUphoff1*,MatthiasanderHeiden2,BrunhildeSchweiger3,HartmutCampe4,DietmarBeier5, CarinaHelmeke6,MartinaLittmann7,WalterHaas2,SilkeBuda2,DanielFaensen2,MarcelFeig2 ,Doris Altmann2,OleWichmann2,TimEckmanns2,UdoBuchholz2 1HessischesLandesPru¨fungs-undUntersuchungsamtimGesundheitswesen,Dillenburg,Germany,2AbteilungEpidemiologiefu¨rInfektio¨seErkrankungen,RobertKoch- Institut, Berlin, Germany, 3Nationales Referenzzentrum fu¨r Influenza, Robert Koch-Institut, Berlin, Germany, 4Bayerisches Landesamt Gesundheit und fu¨r Veterina¨rwesen Sachsen, Dresden, Germany, Lebensmittelsicherheit, Oberschlei?heim, Germany, 5Landesuntersuchungsanstalt fu¨r das Gesundheits - und 6FachbereichHygiene,Landesamtfu¨rVerbraucherschutz,Magdeburg,Germany,7AbteilungGesundheit,Landesamtfu¨rGesundheitundSoziales,Rostock,Germany Abstract DuringtheautumnwaveofthepandemicinfluenzavirusA/(H1N1)2009(pIV)theGermanpopulationwasofferedanAS03- adjuvantedvaccine.Theauthors comparedresultsoftwomethodscalculating theeffectiveness ofthevaccine (VE).The test-negativecase-controlmethoduseddatafromvirologicsurveillanceincludinginfluenza-positiveandnegativepatients. Aninnovativecase-seriesmethodologyexploreddatafromallnationallyreportedlaboratory-confirmedinfluenzacases.The proportionofreportedcasesoccurringinvaccineesduringanassumedunprotectedphaseaftervaccinationwascompared withthat occurring in vaccinees during their assumed protected phase.The test-negative case-control methodincluded 1,749pIVcasesand2,087influenzatest-negativeindividualsofwhom6(0.3%)and36(1.7%),respectively,werevaccinated. The case series method included data from 73,280 cases. VE in the two methods was 79% (95% confidence interval (CI)=35–93%; P=0.007) and 87% (95% CI=78–92%; P,0.001) for individuals less than 14 years of age and 70% (95% CI=245%–94%,P=0.13)and74%(95%CI=64–82%;P,0.001)forindividualsabovet