Effects of a Copper-Deficient Diet on the Biochemistry, Neural Morphology and Behavior of Aged Mice 英文参考文献.docVIP

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Effects of a Copper-Deficient Diet on the Biochemistry, Neural Morphology and Behavior of Aged Mice 英文参考文献.doc

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Effects of a Copper-Deficient Diet on the Biochemistry, Neural Morphology and Behavior of Aged Mice 英文参考文献

EffectsofaCopper-DeficientDietontheBiochemistry, NeuralMorphologyandBehaviorofAgedMice SilviaBolognin1,FedericaPasqualetto1,CarlaMucignat-Caretta2,JanezScancar3,RadmilaMilacic3, PamelaZambenedetti4,BrunoCozzi5*,PaoloZatta1* 1CNR-Institute for Biomedical Technologies, Metalloproteins Unit, Department of Biology, University of Padova, Padova, Italy, 2Department of Human Anatomy and Physiology, University of Padova, Padova, Italy, 3Department of Environmental Sciences, Jozef Stefan Institute, Ljubljana, Slovenia, 4Division of Pathology, General Hospital,Dolo(VE),Italy,5DepartmentofExperimentalVeterinaryScience,UniversityofPadova,Legnaro(PD),Italy Abstract Copper dyshomeostasis has been suggested as an aetiological risk factor for some neurodegenerative diseases, such as Alzheimer’sdisease.However,theprecisemechanismatthebaseofthisinvolvementisstillobscure.Inthiswork,weshow theeffectsofacopper-deficientdietinagedCD1miceandtheinfluenceofsuchadieton:a)theconcentrationofvarious metal ions (aluminium, copper, iron, calcium, zinc) in the main organs and in different brain areas; b) the alteration of metallothioneinsI-IIandtyrosinehydroxylaseimmunopositivityinthebrain;c)behaviouraltests(openfield,pole,predatory aggression,andhabituation/dishabituationsmelltests).Ourdatasuggestedthatthecopper-deficiencywasabletoproduce asortof‘‘dominoeffect’’whichalteredtheconcentrationoftheothertestedmetalionsinthemainorgansaswellasinthe brain,without,however,significantlyaffectingtheanimalbehaviour. Citation: Bolognin S, Pasqualetto F, Mucignat-Caretta C, Scancar J, Milacic R, et al. (2012) Effects of a Copper-Deficient Diet on the Biochemistry, Neural MorphologyandBehaviorofAgedMice.PLoSONE7(10):e47063.doi:10.1371/journal.pone.0047063 Editor:StefanoL.Sensi,UniversityG.D’Annunzio,Italy ReceivedMay9,2012;AcceptedSeptember7,2012;PublishedOctober10,2012 Copyright: ? 2012 Bolognin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, whi