Effects of DHA- Rich n-3 Fatty Acid Supplementation on Gene Expression in Blood Mononuclear Leukocytes The OmegAD Study 英文参考文献.docVIP

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Effects of DHA- Rich n-3 Fatty Acid Supplementation on Gene Expression in Blood Mononuclear Leukocytes The OmegAD Study 英文参考文献.doc

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Effects of DHA- Rich n-3 Fatty Acid Supplementation on Gene Expression in Blood Mononuclear Leukocytes The OmegAD Study 英文参考文献

EffectsofDHA-Richn-3FattyAcidSupplementationon GeneExpressioninBloodMononuclearLeukocytes:The OmegADStudy IngerVedin1*,TommyCederholm3,5,YvonneFreund-Levi2,HansBasun3,4,AnitaGarlind2 ,Gerd Faxe′nIrving2,MariaEriksdotter-Jo¨nhagen2,Lars-OlofWahlund2,IngridDahlman1,JanPalmblad1 1Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden, 2Department of Neurobiology, Caring Sciences and Society, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden, 3Department of Public Health and Caring Sciences, Uppsala University Hospital, Uppsala, Sweden, 4Division of Geriatrics, Uppsala University Hospital, Uppsala, Sweden, 5Division of Clinical Nutrition and Metabolism, Uppsala University Hospital,Uppsala,Sweden Abstract Background:Dietaryfishoil,richinn-3fattyacids(n-3FAs),e.g.docosahexaenoicacid(DHA)andeicosapentaenoicacid (EPA), regulate inflammatory reactions by various mechanisms, e.g. gene activation. However, the effects of long-term treatment with DHA and EPA in humans, using genome wide techniques, are poorly described. Hence, our aim was to determinetheeffectsof6moofdietarysupplementationwithann-3FApreparationrichinDHAonglobalgeneexpression inperipheralbloodmononuclearcells. MethodsandFindings:Inthepresentstudy,bloodsampleswereobtainedfromasubgroupof16patientsoriginatingfrom therandomizeddouble-blind,placebo-controlledOmegADstudy,where174Alzheimerdisease(AD)patientsreceiveddaily either1.7gofDHAand0.6gEPAorplacebofor6months.Inbloodsamplesobtainedfrom11patientsreceivingn-3FA and five placebo, expressions of approximately 8000 genes were assessed by gene array. Significant changes were confirmed by real-time PCR. At 6 months, the n-3 FAs group displayed significant rises of DHA and EPA plasma concentrations,aswellasup-anddown-regulationofnineandtengenes,respectively,wasnoticed.Manyofthesegenes areinvolvedininflammationregulationandneurodegeneration,e.g.CD63,MAN2A1,CASP4,LOC399491,NAIP,andSORL1