Effect of Topical Anaesthetics on Interstitial Colloid Osmotic Pressure in Human Subcutaneous Tissue Sampled by Wick Technique 英文参考文献.docVIP

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Effect of Topical Anaesthetics on Interstitial Colloid Osmotic Pressure in Human Subcutaneous Tissue Sampled by Wick Technique 英文参考文献.doc

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Effect of Topical Anaesthetics on Interstitial Colloid Osmotic Pressure in Human Subcutaneous Tissue Sampled by Wick Technique 英文参考文献

EffectofTopicalAnaestheticsonInterstitialColloid OsmoticPressureinHumanSubcutaneousTissue SampledbyWickTechnique HansJ?rgenTimmGuthe1*,Torbj?rnNedreb?2,3,OlavTenstad2,HelgeWiig2,AnsgarBerg1,4 1DepartmentofPaediatrics,HaukelandUniversityHospital,Bergen,Norway,2SectionofPhysiology,DepartmentofBiomedicine,UniversityofBergen,Bergen,Norway, 3Hyperbaric Medical Unit, Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway, 4Section for Paediatrics, Department of Clinical Medicine,UniversityofBergen,Bergen,Norway Abstract Objectives: To measure colloid osmotic pressure in interstitial fluid (COPi) from human subcutaneous tissue with the modified wick technique in order to determine influence of topical application of anaesthetics, dry vs. wet wick and implantationtimeonCOPi. MaterialandMethods:In50healthyvolunteersinterstitialfluid(IF)wascollectedbysubcutaneousimplantationofmulti- filamentousnylonwicks.Studysubjectswereallocatedtotwogroups;oneforcomparingCOPiobtainedfromdryandsaline soakedwicks,andoneforcomparingCOPifromunanaesthetizedskin,andskinafterapplicationofaeutecticmixtureof localanaesthetic(EMLAH,AstraZeneca)cream.IFwassampledfromtheskinoftheshoulders,andimplantationtimewas 30,60,75,90and120min.Colloidosmoticpressurewasmeasuredwithacolloidosmometer.Painassessmentduringthe procedurewascomparedforEMLAcreamandnotopicalanaesthesiausingavisualanaloguescale(VAS)inasubgroupof 10subjects. Results: There werenosignificantdifferences betweenCOPi obtainedfromdry comparedtowetwicks, except thatthe valuesafter75and90min.weresomewhathigherforthedrywicks.TopicalanaesthesiawithEMLAcreamdidnotaffect COPi values. COPi decreased from 30 to 75min. of implantation (23.264.4mmHg to 19.662.9mmHg, p=0.008) and subsequentlytendedtoincreaseuntil120min.EMLAcreamresultedinsignificantlowerVASscorefortheprocedure. Conclusion: COPi from subcutaneous tissue was easily obtained and fluid harvesting was well tolerated when topical anaestheticwasused.ThedifferenceinC