Effect of CCR5-Δ32 Heterozygosity on HIV-1 Susceptibility A Meta-Analysis 英文参考文献.docVIP

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Effect of CCR5-Δ32 Heterozygosity on HIV-1 Susceptibility A Meta-Analysis 英文参考文献.doc

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Effect of CCR5-Δ32 Heterozygosity on HIV-1 Susceptibility A Meta-Analysis 英文参考文献

EffectofCCR5-D32HeterozygosityonHIV-1 Susceptibility:AMeta-Analysis SiJieLiu,ChuiJinKong,JieWu,HaoYing,HuanZhangZhu* TheStateKeyLaboratoryofGeneticEngineering,InstituteofGenetics,SchoolofLifeScience,FudanUniversity,Shanghai,China Abstract Background:Sofar,manystudieshaveinvestigatedthedistributionofCCR5genotypebetweenHIV-1infectedpatientsand uninfected people. However, no definite results have been put forward about whether heterozygosity for a 32-basepair deletioninCCR5gene(CCR5-D32)canaffectHIV-1susceptibility. Methods: We performed a meta-analysis of 18 studies including more than 12000 subjects for whom the CCR5-D32 polymorphismwasgenotyped.Oddsratio(OR)with95%confidenceinterval(CI)wereemployedtoassesstheassociation ofCCR5-D32polymorphismwithHIV-1susceptibility. Results:Comparedwiththewild-typeCCR5homozygotes,thepooledORforCCR5-D32heterozygoteswas1.02(95%CI, 0.88–1.19)forhealthycontrols(HC)and0.95(95%CI,0.71–1.26)forexposeduninfected(EU)controls.Similarresultswere foundinstratifiedanalysisbyethnicity,samplesizeandmethodofCCR5-D32genotyping. Conclusions:Themeta-analysisindicatedthatHIV-1susceptibilityisnotsignificantlyaffectedbyheterozygosityforCCR5- D32. Citation: Liu S, Kong C, Wu J, Ying H, Zhu H (2012) Effect of CCR5-D32 Heterozygosity on HIV-1 Susceptibility: A Meta-Analysis. PLoS ONE 7(4): e35020. doi:10.1371/journal.pone.0035020 Editor:K.T.Jeang,NationalInstituteofHealth,UnitedStatesofAmerica ReceivedOctober29,2011;AcceptedMarch8,2012;PublishedApril4,2012 Copyright:?2012Liuetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding: This work is supported by National Grand Program on Key Infectious Disease (2012ZX10001-003), National Natural Science Funding of China (No.Thefundershadnoroleinstudydesign,datacollectionandanalysis,decisiontopublish,orpreparationofthemanuscript. CompetingInteres