Effects of Different Up-Dosing Regimens for Hymenoptera Venom Immunotherapy on Serum CTLA-4 and IL-10 英文参考文献.docVIP

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Effects of Different Up-Dosing Regimens for Hymenoptera Venom Immunotherapy on Serum CTLA-4 and IL-10 英文参考文献.doc

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Effects of Different Up-Dosing Regimens for Hymenoptera Venom Immunotherapy on Serum CTLA-4 and IL-10 英文参考文献

EffectsofDifferentUp-DosingRegimensfor HymenopteraVenomImmunotherapyonSerumCTLA-4 andIL-10 AnnaMariaRiccio1,DanieleSaverino2,GiampaolaPesce3,AnthiRogkakou1,MaurizioSeverino4, PatriziaBonadonna5,ErminiaRidolo6,MarinaMauro7,GiorgioWalterCanonica1,MarcelloBagnasco3, GiovanniPassalacqua1* 1Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy, 2Section of Human Anatomy, Department of Experimental Medicine,UniversityofGenoa,Genoa,Italy,3MedicalandRadiomethabolicTherapy,DepartmentofInternalMedicine,UniversityofGenoa,Genoa,Italy,4AllergyUnit, OspedaleSanGiovannidiDio,Florence,Italy,5AllergyService,VeronaGeneralHospital,Verona,Italy,6ExperimentalandInternalMedicine,UniversityofParma,Parma, Italy,7AllergyUnit,Sant’AnnaHospital,Como,Italy Abstract Background:CytotoxicTlymphocyteassociatedantigen-4(CTLA-4)isinvolvedintheactivationpathwaysofTlymphocytes. IthasbeenshownthatthecirculatingformofCTLA-4iselevatedinpatientswithhymenopteraallergyandcanbedown regulatedbyimmunotherapy. Objective:toassesstheeffectsonCTLA-4ofvenomimmunotherapy,givenwithdifferentinductionprotocols:conventional (6weeks),rush(3days)orultrarush(1day). Methods:Serafrompatientswithhymenopteraallergywerecollectedatbaselineandattheendoftheinductionphase. CTLA-4 and IL-10 were assayed in the same samples. A subset of patients were assayed also after 12 months of VIT maintenance. Results:Ninety-fourpatientswerestudied.Ofthem,50underwenttheconventionalinduction,20therushand24theultra- rush. Soluble CTLA-4 was detectable in all patients at baseline, and significantly decreased at the end of the induction, irrespectiveofitsduration.Ofnote,asignificantdecreaseofsCTLA-4couldbeseenalreadyat24hours.Inparallel,IL-10 significantly increased at the end of the induction. At 12 months, sCTLA-4 remained low, whereas IL-10 returned to the baselinevalues. Conclusions: Serum CTLA4 is an early marker of the immunological effects of venom immunotherapy, and its changes persistafterone