Effect of Surfaces on Amyloid Fibril Formation 英文参考文献.docVIP

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Effect of Surfaces on Amyloid Fibril Formation 英文参考文献.doc

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Effect of Surfaces on Amyloid Fibril Formation 英文参考文献

EffectofSurfacesonAmyloidFibrilFormation BradleyMoores1,ElizabethDrolle2,SimonJ.Attwood1,JanetSimons2,ZoyaLeonenko1,2* 1DepartmentofPhysicsandAstronomy,UniversityofWaterloo,Waterloo,Ontario,Canada,2DepartmentofBiology,UniversityofWaterloo,Waterloo,Ontario,Canada Abstract Usingatomicforcemicroscopy(AFM)weinvestigatedtheinteractionofamyloidbeta(Ab)(1–42)peptidewithchemically modifiedsurfacesinordertobetterunderstandthemechanismofamyloidtoxicity,whichinvolvesinteractionofamyloid withcellmembranesurfaces.WecomparedthestructureanddensityofAbfibrilsonpositivelyandnegativelychargedas wellashydrophobicchemically-modifiedsurfacesatphysiologicallyrelevantconditions.Wereportthatduetothecomplex distribution of charge and hydrophobicityamyloid oligomers bindtoall types of surfaces investigated (CH3,COOH, and NH2) although the charge and hydrophobicity of surfaces affected the structure and size of amyloid deposits as well as surface coverage. Hydrophobic surfaces promote formation of spherical amorphous clusters, while charged surfaces promote protofibril formation. We used the nonlinear Poisson-Boltzmann equation (PBE) approach to analyze the electrostaticinteractionsofamyloidmonomersandoligomerswithmodifiedsurfacestocomplementourAFMdata. Citation: MooresB,Drolle E,Attwood SJ,Simons J,Leonenko Z(2011) Effect ofSurfaces onAmyloid Fibril Formation. PLoSONE 6(10): e25954. doi:10.1371/ journal.pone.0025954 Editor:IgorSokolov,ClarksonUniversity,UnitedStatesofAmerica ReceivedJune7,2011;AcceptedSeptember14,2011;PublishedOctober10,2011 Copyright: ? 2011 Moores et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkwassupportedbytheNaturalScienceandEngineeringCouncilofCanada(NSERC),http://www.nserc-crsng.gc.ca,CanadaFoundationfor Innovation,www.innovation.ca,andOntarioMinistryofResearchandInnovatio