Enumeration of CD4+ T-Cells Using a Portable Microchip Count Platform in Tanzanian HIV-Infected Patients 英文参考文献.docVIP

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Enumeration of CD4+ T-Cells Using a Portable Microchip Count Platform in Tanzanian HIV-Infected Patients 英文参考文献.doc

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EnumerationofCD4T-CellsUsingaPortableMicrochipCountPlatforminTanzanianHIV-InfectedPatients英文参考文献

EnumerationofCD4+T-CellsUsingaPortableMicrochip CountPlatforminTanzanianHIV-InfectedPatients SangJunMoon1,UmutAtakanGurkan1,JeffreyBlander1,2,WafaieW.Fawzi3,SaidAboud4 ,Ferdinand Mugusi5,DanielR.Kuritzkes6,UtkanDemirci1,7* 1Demirci Bio-Acoustic MEMS Laboratory, Center for Biomedical Engineering, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United StatesofAmerica,2DepartmentofEpidemiology,HarvardMedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica,3DepartmentofNutrition,Departmentof Epidemiology, Department of Global Health and Population, Harvard School of Public Health, Boston, Massachusetts, United States of America, 4Department of MicrobiologyandImmunology,MuhimbiliUniversityofHealthandAlliedSciences,DaresSalaam,Tanzania,5DepartmentofInternalMedicine,MuhimbiliUniversityof HealthandAlliedSciences,DaresSalaam,Tanzania,6SectionofRetroviralTherapeutics,BrighamandWomen’sHospital,HarvardMedicalSchool,Boston,Massachusetts, UnitedStatesofAmerica,7Harvard-MITHealthSciencesandTechnology,Cambridge,Massachusetts,UnitedStatesofAmerica Abstract Background: CD4+ T-lymphocyte count (CD4 count) is astandard method used to monitor HIV-infected patients during anti-retroviral therapy (ART). The World Health Organization (WHO) has pointed out or recommended that a handheld, point-of-care,reliable,andaffordableCD4countplatformisurgentlyneededinresource-scarcesettings. Methods:HIV-infectedpatientbloodsamplesweretestedatthepoint-of-careusingaportableandlabel-freemicrochip CD4countplatformthatwehavedeveloped.Atotalof130HIV-infectedpatientsampleswerecollectedthatincluded16 de-identifiedleftoverbloodsamplesfromBrighamandWomen’sHospital(BWH),and114leftoversamplesfromMuhimbili UniversityofHealthandAlliedSciences(MUHAS)enrolledintheHIVandAIDScareandtreatmentcentersintheCityofDar esSalaam,Tanzania.ThetwodatagroupsfromBWHandMUHASwereanalyzedandcomparedtothecommonlyaccepted CD4countreferencemethod(FACSCalibursystem). Results:Theportable,batteryoperatedandmi