Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population 英文参考文献.docVIP

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Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population 英文参考文献.doc

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Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population 英文参考文献

Epigenome-WideScansIdentifyDifferentially MethylatedRegionsforAgeandAge-Related PhenotypesinaHealthyAgeingPopulation JordanaT.Bell1,2.*,Pei-ChienTsai2.,Tsun-PoYang3,RuthPidsley4,JamesNisbet3,DanielGlass2, MassimoMangino2,GuangjuZhai2,5,FengZhang2,AnaValdes2,So-YounShin3,EmmaL.Dempster4, RobinM.Murray6,ElinGrundberg2,3,AsaK.Hedman1,AlexandraNica7,KerrinS.Small2, TheMuTHER Consortium{,EmmanouilT.Dermitzakis7,MarkI.McCarthy1,8,9,JonathanMill4,TimD.Spector2*, PanosDeloukas3* 1WellcomeTrustCentreforHumanGenetics,UniversityofOxford,Oxford,UnitedKingdom,2DepartmentofTwinResearchandGeneticEpidemiology,King’sCollege London, London, United Kingdom, 3Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, 4MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King’s College London, London, United Kingdom, 5Discipline of Genetics, Faculty of Medicine, Memorial UniversityofNewfoundland,St.John’s,Canada,6DepartmentofPsychosisStudies,InstituteofPsychiatry,King’sCollegeLondon,London,UnitedKingdom,7Department ofGeneticMedicineandDevelopment,UniversityofGeneva,Geneva,Switzerland,8OxfordCentreforDiabetes,Endocrinology,andMetabolism,UniversityofOxford, ChurchillHospital,Oxford,UnitedKingdom,9OxfordNationalInstituteforHealthResearchBiomedicalResearchCentre,ChurchillHospital,Oxford,UnitedKingdom Abstract Age-related changes inDNA methylation havebeenimplicatedin cellular senescence andlongevity, yetthecausesand functionalconsequencesofthesevariantsremainunclear.Toelucidatetheroleofage-relatedepigeneticchangesinhealthy ageingandpotentiallongevity,wetestedforassociationbetweenwhole-bloodDNAmethylationpatternsin172female twinsaged32to80withageandage-relatedphenotypes.Twin-basedDNAmethylationlevelsat26,690CpG-sitesshowed evidence for mean genome-wide heritability of 18%, which was supported by the identification of 1,537 CpG-sites with methylation QTLs in cis at FDR 5%. We performed genome-wide analyses to discover differe