Episodic Sexual Transmission of HIV Revealed by Molecular Phylodynamics 英文参考文献.docVIP

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Episodic Sexual Transmission of HIV Revealed by Molecular Phylodynamics 英文参考文献.doc

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Episodic Sexual Transmission of HIV Revealed by Molecular Phylodynamics 英文参考文献

o PL SMEDICINE EpisodicSexualTransmissionofHIV RevealedbyMolecularPhylodynamics Fraser Lewis1[¤,Gareth J.Hughes1[,Andrew Rambaut1,Anton Pozniak2,Andrew J.Leigh Brown1* 1 Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland, 2 Chelsea and Westminster Hospital, London, United Kingdom Funding:Thisworkwasfundedby theWellcomeTrustandtheMedical ResearchCouncil.Thefundershad noroleinstudydesign,data collectionandanalysis,decisionto publish,orpreparationofthe manuscript. ABSTRACT Background The structure of sexual contact networks plays a key role in the epidemiology of sexually transmitted infections, and their reconstruction from interview data has provided valuable insights into the spread of infection. For HIV, the long period of infectivity has made the interpretationofcontactnetworksmoredifficult,andmajordiscrepancieshavebeenobserved between the contact network and the transmission network revealed by viral phylogenetics. ThehighrateofHIVevolutioninprincipleallowsfordetailedreconstructionoflinksbetween virus from different individuals, but often sampling has been too sparse to describe the structure of the transmission network. The aim of this study was to analyze a high-density sampleofanHIV-infectedpopulationusingrecentlydevelopedtechniquesinphylogeneticsto infertheshort-termdynamicsoftheepidemicamongmenwhohavesexwithmen(MSM). CompetingInterests:ALPreports receivingconsultingandlecturefees fromBristol-MyersSquibb,Gilead Sciences,andGlaxoSmithKline.The otherauthorsdeclarethattheyhave nocompetinginterests. AcademicEditor:Christopher Pilcher,UniversityofCaliforniaSan Francisco,UnitedStatesofAmerica Citation:LewisF,HughesGJ, RambautA,PozniakA,LeighBrown AJ(2008)Episodicsexual transmissionofHIVrevealedby molecularphylodynamics.PLoSMed 5(3):e50.doi:10.1371/journal.pmed. 0050050 MethodsandFindings Sequences of the protease and reverse transcriptase coding regions from 2,126 patients, predominantlyMSM,fromLondonw