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Ethnic-Specific Differences in Vitamin D Status Is Associated with Adiposity 英文参考文献.docVIP

Ethnic-Specific Differences in Vitamin D Status Is Associated with Adiposity 英文参考文献.doc

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Ethnic-Specific Differences in Vitamin D Status Is Associated with Adiposity 英文参考文献

Ethnic-SpecificDifferencesinVitaminDStatusIs AssociatedwithAdiposity DianC.Sulistyoningrum1,TimothyJ.Green2,ScottA.Lear3,AngelaM.Devlin1,4* 1Department of Pathology and Laboratory Medicine, University of British Columbia, Child and Family Research Institute, Vancouver, Canada, 2Department of Food NutritionandHealth,UniversityofBritishColumbia,ChildandFamilyResearchInstitute,Vancouver,Canada,3FacultyofHealthSciences,SimonFraserUniversityand Division of Cardiology, Providence Health Care, Vancouver, Canada, 4Department of Pediatrics, University of British Columbia, Child and Family Research Institute, Vancouver,Canada Abstract Background:Lowcirculating25hydroxyvitaminD[25(OH)D]concentrationsarecommoninobesity(BMI$30kg/m2)anda negative relationship with body fat distribution has recently been reported. Ethnic-specific differences in body fat distributionhavebeendescribedwithSouthAsiansarereportedtohavegreatervisceraladiposetissue(VAT),whichcould influencecirculating25(OH)Dconcentrations.Theobjectiveofthisstudyistoinvestigatetherelationshipbetweenplasma 25(OH)D,adiposity,andbodyfatdistributioninEuropeansandSouthAsians. Methods/PrincipalFindings:187Europeansand192SouthAsianswereassessedfordemographics,anthropometrics,and plasma25(OH)Dconcentrations.Subcutaneousadiposetissue(SAT)andVATwerequantifiedbyCTscan,andpercentbody fat by DEXA. Data were assessed by general linear models. South Asians had lower (P,0.001) plasma 25(OH)D concentrations and higher VAT (P=0.04) than Europeans. Plasma 25(OH)D concentrations were negatively (P,0.05) associatedwithBMI,waistcircumference,percentbodyfat,totaladiposetissue,VAT,andSATinunadjustedmodelsand negatively(P,0.05)associatedwithVAT,SAT,andpercentbodyfatafteradjustingforBMI,ethnicity,age,andseasonof bloodcollectioninmalesandfemales.Whenpercentbodyfat,VAT,andSATwereincludedinthesamemodel,onlyVAT remainednegatively(P,0.05)associatedwithplasma25(OH)Dconcentrations.Ethnicityremainedsignificantinallmodels (P,0.001). Conclusion:Comparedto

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