Evolution of Asthma Severity in a Cohort of Young Adults Is There Any Gender Difference 英文参考文献.docVIP

EvolutionofAsthmaSeverityinaCohortofYoung Adults:IsThereAnyGenderDifference? ChantalRaherison1*,ChristerJanson2,DeborahJarvis3,PeterBurney3,LuciaCazzoletti4,Robertode Marco4,Franc?oiseNeukirch5,BenedicteLeynaert5 1Department of Respiratory Diseases Haut-Le′ve`que CHU Bordeaux, EA 3672, ISPED, Universite′ Bordeaux 2, Bordeaux, France, 2Department of Medical Sciences: RespiratoryMedicineandAllergology,UppsalaUniversity,Uppsala,Sweden,3DepartmentofPublicHealthSciences,CapitalHouse,London,UnitedKingdom,4Unitof EpidemiologyandMedicalStatistics,DepartmentofMedicineandPublicHealth,UniversityofVerona,Verona,Italy,5Epide′miologiedesMaladiesRespiratoires,INSERM U700,Faculte′ deMe′decineXavier,Bichat,Paris Abstract Introduction: Little is known about the distribution of asthma severity in men and women in the general population. The objectiveofourstudywastodescribeasthmaseverityandchangeinseverityaccordingtogenderinacohortofadultasthmatics Methods:Subjectswithasthmawereidentifiedfromrandomsamplesofthe22to44year-oldsfromthegeneralpopulation, screenedforasthmafrom1991to1993in48centersfrom22countriesandfollowed-upduring1998–2002,aspartofthe EuropeanCommunityRespiratoryHealthSurvey(ECRHS).Allparticipantstofollow-upwithcurrentasthmaatbaselinewere eligible for the analysis. To assess change over the follow-up, asthma severity at the two surveys was defined using standardized data on respiratory symptoms, lung function and medication according to the Global Initiative for Asthma (GINA)Guidelines.Anotherquantitativescore(Ronchetti)furtherconsideringhospitalizationswasalsoanalysed. Results:Thestudyincluded685subjectswithasthmafollowed-upoverameanperiodof8.65yr(min4.3-max11.7).Atbaseline, asthmaseverityaccordingtoGINAwasdistributedasintermittent:40.7%,31.7%asmildpersistent,14%asmoderatepersistent, and13.5%asseverepersistent.UsingtheRonchettiscorederivedclassification,thedistributionofasthmaseveritywas58%mild, (intermittent and mild persistent), 25.8% moderate, and 15.4% severe. Whatev