Excess Mortality Rate During Adulthood Among Danish Adoptees 英文参考文献.docVIP

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Excess Mortality Rate During Adulthood Among Danish Adoptees 英文参考文献.doc

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Excess Mortality Rate During Adulthood Among Danish Adoptees 英文参考文献

ExcessMortalityRateDuringAdulthoodAmongDanish Adoptees LiselottePetersen1,2*,ThorkildI.A.S?rensen1,ErikLykkeMortensen3,PerKraghAndersen4 1InstituteofPreventiveMedicine,CopenhagenUniversityHospital,Copenhagen,Denmark,2NationalCentreforRegister-basedResearch,UniversityofAarhus,Aarhus, Denmark, 3Institute of Public Health and Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark, 4Department of Biostatistics, University of Copenhagen,Copenhagen,Denmark Abstract Backgroundandobjective:Adoptionstudieshavebeenusedtodisentangletheinfluenceofgenesfromsharedfamilial environmentonvarioustraitsanddiseaserisks.However,boththefactorsleadingtoadoptionandlivingasanadopteemay biasthestudieswithregardtotherelativeinfluenceofgenesandenvironmentcomparedtothegeneralpopulation.The aimwastoinvestigatewhetherthecohortofdomesticadopteesusedforthesestudiesinDenmarkissimilartothegeneral populationwithrespecttoall-causemortalityandcause-specificmortalityrates. Methods:13,111adopteesborninDenmarkin1917,orlater,andadoptedin1924to1947werecomparedtoallDanes from the same birth cohorts using standardized mortality ratios (SMR). The 12,729 adoptees alive in 1970 were similarly comparedtoallDanesusingSMRaswellascause-specificSMR. Results: The excess in all-cause mortality before age 65 years in adoptees was estimated to be 1.30 (95% CI 1.26–1.35). Significantexcessmortalitybeforeage65yearswasalsoobservedforinfections,vasculardeaths,cancer,alcohol-related deathsandsuicide.Analysesincludingdeathsafterage65generallyshowedslightlylessexcessinmortality,buttheexcess wassignificantforall-causemortality,cancer,alcohol-relateddeathsandsuicides. Conclusion:Adopteeshaveanincreasedall-causemortalitycomparedtothegeneralpopulation.Allmajorspecificcauses ofdeathcontributed,andthehighestexcessisseenforalcohol-relateddeaths. Citation:PetersenL,S?rensenTIA,MortensenEL,AndersenPK(2010)ExcessMortalityRateDuringAdulthoodAmongDanishAdoptees.PLoSONE5(12):e14365. doi:10.1371/journal.pone.0014365 Editor: