Expression Profiling the Temperature-Dependent Amphibian Response to Infection by Batrachochytrium dendrobatidis 英文参考文献.docVIP
- 1、本文档共10页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Expression Profiling the Temperature-Dependent Amphibian Response to Infection by Batrachochytrium dendrobatidis 英文参考文献
ExpressionProfilingtheTemperature-Dependent
AmphibianResponsetoInfectionbyBatrachochytrium
dendrobatidis
LaiaRibas1,Ming-ShiLi2,BenjaminJ.Doddington1,JacquesRobert3,JudithA.Seidel1,J.SimonKroll2,
LyleB.Zimmerman4,NicholasC.Grassly1,TrentonW.J.Garner5,MatthewC.Fisher1*
1Department of Infectious Disease Epidemiology, Imperial College London, United Kingdom, 2Department of Paediatrics, Imperial College London, London, United
Kingdom,3University ofRochester MedicalCentre, Rochester, New York, UnitedStates ofAmerica, 4Developmental Biology,NationalInstitute for MedicalResearch,
London,UnitedKingdom,5InstituteofZoology,Regent’sPark,London,UnitedKingdom
Abstract
Amphibians are experiencing a panzootic of unprecedented proportions caused by the emergence of Batrachochytrium
dendrobatidis(Bd).However,allspeciesarenotequallyatriskofinfection,andriskisfurthermodifiedbyenvironmental
variables, specifically temperature. In order to understand how, and when, hosts mount a response to Bd we analysed
infection dynamics and patterns of gene expression in the model amphibian species Silurana (Xenopus) tropicalis.
Mathematicalmodellingofinfectiondynamicsdemonstratetheexistenceofatemperature-dependentprotectiveresponse
thatislargelyindependentoftheintrinsicgrowth-rateofBd.Usingtemporalexpression-profilingbymicroarraysandqRT-
PCR,wecharacterisethisresponseinthemainamphibianlymphoidtissue,thespleen.WedemonstratethatclearanceofBd
atthehost-optimaltemperatureisnotclearlyassociatedwithanadaptiveimmuneresponse,butratheriscorrelatedwith
the induction of components of host innate immunity including the expression of genes that are associated with the
production of the antimicrobial skin peptide preprocareulein (PPCP) as well as inflammatory responses. We find that
adaptiveimmunityappearstobelackingathost-optimaltemperatures.ThissuggeststhateitherBddoesnotstimulate,or
suppresses, adaptive immunity, or that trade-offs exist between innate and adaptive limbs of the amphibian immune
system.Atcol
您可能关注的文档
- ExpI and PhzI Are Descendants of the Long Lost Cognate Signal Synthase for SdiA 英文参考文献.doc
- Explaining Away the Body Experiences of Supernaturally Caused Touch and Touch on Non-Hand Objects within the Rubber Hand Illusion 英文参考文献.doc
- Explaining Dog Wolf Differences in Utilizing Human Pointing Gestures Selection for Synergistic Shifts in the Development of Some Social Skills 英文参考文献.doc
- Expert Financial Advice Neurobiologically “Offloads” Financial Decision-Making under Risk 英文参考文献.doc
- Explaining Lengths and Shapes of Yeast by Scaling Arguments 英文参考文献.doc
- Expert Status and Performance 英文参考文献.doc
- Experimental Transmission of Leishmania infantum by Two Major Vectors A Comparison between a Viscerotropic and a Dermotropic Strain 英文参考文献.doc
- Explaining the Evolution of Warning Coloration Secreted Secondary Defence Chemicals May Facilitate the Evolution of Visual Aposematic Signals 英文参考文献.doc
- Experimental ‘Jet Lag’ Inhibits Adult Neurogenesis and Produces Long-Term Cognitive Deficits in Female Hamsters 英文参考文献.doc
- Explicit Logic Circuits Predict Local Properties of the Neocortex's Physiology and Anatomy 英文参考文献.doc
文档评论(0)