Factors Associated with Findings of Published Trials of Drug–Drug Comparisons Why Some Statins Appear More Efficacious than Others 英文参考文献.docVIP

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Factors Associated with Findings of Published Trials of Drug–Drug Comparisons Why Some Statins Appear More Efficacious than Others 英文参考文献.doc

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Factors Associated with Findings of Published Trials of Drug–Drug Comparisons Why Some Statins Appear More Efficacious than Others 英文参考文献

o PL SMEDICINE FactorsAssociatedwithFindingsofPublished TrialsofDrug–DrugComparisons:WhySome StatinsAppearMoreEfficaciousthanOthers Lisa Bero1*,Fieke Oostvogel2,Peter Bacchetti3,Kirby Lee4 1 Clinical Pharmacy and Health Policy, University of California, San Francisco, California, United States of America, 2 Department of Mathematics, University of Leiden, The Netherlands, 3 Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States of America, 4 Department of Clinical Pharmacy,UniversityofCalifornia,SanFrancisco,California,UnitedStatesofAmerica Funding:Thisresearchwas supportedbytheCalifornia Tobacco-RelatedDiseaseResearch ProgramGrant13RT-0108(principal investigator,L.A.Bero).Thefunders hadnoroleinstudydesign,data collectionandanalysis,decisionto publish,orpreparationofthe manuscript. ABSTRACT Background Published pharmaceutical industry–sponsored trials are more likely than non-industry- sponsoredtrialstoreportresultsandconclusionsthatfavordrugoverplacebo.Littleisknown aboutpotentialbiasesindrug–drugcomparisons.Thisstudyexaminedassociationsbetween researchfundingsource,studydesigncharacteristicsaimedatreducingbias,andotherfactors that potentially influence results and conclusions in randomized controlled trials (RCTs) of statin–drugcomparisons. CompetingInterests:Theauthors havedeclaredthatnocompeting interestsexist. AcademicEditor:Alessandro Liberati,ItalianCochraneCentre, Italy MethodsandFindings Citation:BeroL,OostvogelF, BacchettiP,LeeK(2007)Factors associatedwithfindingsof publishedtrialsofdrug–drug comparisons:Whysomestatins appearmoreefficaciousthanothers. PLoSMed4(6):e184.doi:10.1371/ journal.pmed.0040184 This is a cross-sectional study of 192 published RCTs comparing a statin drug to another statin drug or non-statin drug. Data on concealment of allocation, selection bias, blinding, samplesize,disclosed fundingsource,financialtiesofauthors,resultsforprimary outcomes, andauthorconclusionswereext