Familial Resemblance of Borderline Personality Disorder Features Genetic or Cultural Transmission 英文参考文献.docVIP

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Familial Resemblance of Borderline Personality Disorder Features Genetic or Cultural Transmission 英文参考文献.doc

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Familial Resemblance of Borderline Personality Disorder Features Genetic or Cultural Transmission 英文参考文献

FamilialResemblanceofBorderlinePersonalityDisorder Features:GeneticorCulturalTransmission? MarijnA.Distel1*,IreneRebollo-Mesa1,GonnekeWillemsen1,CatherineA.Derom2,TimothyJ.Trull3, NicholasG.Martin4,DorretI.Boomsma1 1Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands, 2Department of Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium, 3Department of Psychological Sciences, University of Missouri-Columbia, Columbia, Missouri, United States of America, 4Queensland Institute of MedicalResearch,Brisbane,Australia Abstract Borderlinepersonalitydisorderisaseverepersonalitydisorderforwhichgeneticresearchhasbeenlimitedtofamilystudies and classical twin studies. These studies indicate that genetic effects explain 35 to 45% of the variance in borderline personalitydisorderandborderlinepersonalityfeatures.However,effectsofnon-additive(dominance)geneticfactors,non- randommatingandculturaltransmissionhavegenerallynotbeenexplored.Inthepresentstudyanextendedtwin-family design was applied to self-report data of twins (N=5,017) and their siblings (N=1,266), parents (N=3,064) and spouses (N=939) from 4,015 families, to estimate the effects of additive and non-additive genetic and environmental factors, culturaltransmissionandnon-randommatingonindividualdifferencesinborderlinepersonalityfeatures.Resultsshowed that resemblance among biological relatives could completely be attributed to genetic effects. Variation in borderline personalityfeatureswasexplainedbyadditivegenetic(21%;95%CI17–26%)anddominantgenetic(24%;95%CI17–31%) factors.Environmentalinfluences(55%;95%CI51–60%)explainedtheremainingvariance.Significantresemblancebetween spouseswasobserved,whichwasbestexplainedbyphenotypicassortativemating,butithadonlyasmalleffectonthe geneticvariance(1%ofthetotalvariance).Therewasnoeffectofculturaltransmissionfromparentstooffspring. Citation:DistelMA,Rebollo-MesaI,WillemsenG,DeromCA,TrullTJ,etal.(2009)FamilialResemblanceofBorderlinePersonal