Expression of Sympathetic Nervous System Genes in Lamprey Suggests Their Recruitment for Specification of a New Vertebrate Feature 英文参考文献.docVIP

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Expression of Sympathetic Nervous System Genes in Lamprey Suggests Their Recruitment for Specification of a New Vertebrate Feature 英文参考文献.doc

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Expression of Sympathetic Nervous System Genes in Lamprey Suggests Their Recruitment for Specification of a New Vertebrate Feature 英文参考文献

ExpressionofSympatheticNervousSystemGenesin LampreySuggestsTheirRecruitmentforSpecificationof aNewVertebrateFeature DanielaHa¨ming.,MarcosSimoes-Costa.,BenjaminUy,JonathanValencia,TatjanaSauka-Spengler, MarianneBronner-Fraser* DivisionofBiology,CaliforniaInstituteofTechnology,Pasadena,California,UnitedStatesofAmerica Abstract Thesealampreyisabasal,jawlessvertebratethatpossessesmanyneuralcrestderivatives,butlacksjawsandsympathetic ganglia.Thisraisesthepossibilitythatthefactorsinvolvedinsympatheticneurondifferentiationwereeitheragnathostome innovation or already present in lamprey, but serving different purposes. To distinguish between these possibilities, we isolated lamprey homologues of transcription factors associated with peripheral ganglion formation and examined their deploymentinlampreyembryos.WefurtherperformedDiIlabelingoftheneuraltubecombinedwithneuronalmarkersto testifneuralcrest-derivedcellsmigratetoanddifferentiateinsitescolonizedbysympatheticgangliainjawedvertebrates. Consistent with previous anatomical data in adults, our results in lamprey embryos reveal that neural crest cells fail to migrate ventrally to form sympathetic ganglia, though they do form dorsal root ganglia adjacent to the neural tube. Interestingly, however, paralogs of the battery of transcription factors that mediate sympathetic neuron differentiation (dHand,Ascl1andPhox2b)arepresentinthelampreygenomeandexpressedinvarioussitesintheembryo,butfailto overlap in any ganglionic structures. This raises the intriguing possibility that they may have been recruited during gnathostomeevolutiontoanewfunctioninaneuralcrestderivative. Citation:Ha¨ming D,Simoes-CostaM,UyB,ValenciaJ,Sauka-SpenglerT,etal.(2011)ExpressionofSympatheticNervousSystemGenesinLampreySuggests TheirRecruitmentforSpecificationofaNewVertebrateFeature.PLoSONE6(10):e26543.doi:10.1371/journal.pone.0026543 Editor:FerencMueller,UniversityofBirmingham,UnitedKingdom ReceivedApril29,2011;AcceptedSeptember28,2011;PublishedOctober27,20