Experimental Oral Transmission of Chronic Wasting Disease to Reindeer (Rangifer tarandus tarandus) 英文参考文献.docVIP

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Experimental Oral Transmission of Chronic Wasting Disease to Reindeer (Rangifer tarandus tarandus) 英文参考文献.doc

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Experimental Oral Transmission of Chronic Wasting Disease to Reindeer (Rangifer tarandus tarandus) 英文参考文献

ExperimentalOralTransmissionofChronicWasting DiseasetoReindeer(Rangifertarandustarandus) GordonB.Mitchell1,ChristinaJ.Sigurdson2,3,KatherineI.O’Rourke4,JamesAlgire1,NoelP.Harrington1, InesWalther1,TerryR.Spraker5,AruBalachandran1* 1National and OIE Reference Laboratory for Scrapie and CWD, Canadian Food Inspection Agency, Ottawa Laboratory – Fallowfield, Ottawa, Ontario, Canada, 2DepartmentsofPathologyandMedicine,UniversityofCalifornia,SanDiego,LaJolla,California,UnitedStatesofAmerica,3DepartmentofPathology,Microbiologyand Immunology,UniversityofCalifornia,Davis,California,UnitedStatesofAmerica,4AnimalDiseaseResearchUnit,AgriculturalResearchService,UnitedStatesDepartment of Agriculture, Pullman, Washington, United States of America, 5Veterinary Diagnostic Laboratory, Colorado State University, Fort Collins, Colorado, United States of America Abstract Chronicwastingdisease(CWD),atransmissiblespongiformencephalopathyofcervids,remainsprevalentinNorthAmerican elk,white-taileddeerandmuledeer.AnaturalcaseofCWDinreindeer(Rangifertarandustarandus)hasnotbeenreported despitepotentialhabitatoverlapwithCWD-infecteddeerorelkherds.Thisstudyinvestigatestheexperimentaltransmission ofCWDfromelkorwhite-taileddeertoreindeerbytheoralrouteofinoculation.Ante-mortemtestingofthethreereindeer exposedtoCWDfromwhite-taileddeeridentifiedtheaccumulationofpathologicalPrP(PrPCWD)intherecto-analmucosa associatedlymphoidtissue(RAMALT)oftworeindeerat13.4monthspost-inoculation.TerminalCWDoccurredinthetwo RAMALT-positivereindeerat18.5and20monthspost-inoculationwhileoneotherreindeerinthewhite-taileddeerCWD inoculumgroupandnoneofthe3reindeerexposedtoelkCWDdevelopeddisease.TissuedistributionanalysisofPrPCWD in CWD-affectedreindeerrevealedwidespreaddepositionincentralandperipheralnervoussystems,lymphoreticulartissues, thegastrointestinaltract,neuroendocrinetissuesandcardiacmuscle.Analysisofprionproteingene(PRNP)sequencesin the6reindeeridentifiedpolymorphismsatresidues2(V/M),129(G/S),138(S/N)and169(V/M).Th