Fc-Epsilon-RI, the High Affinity IgE-Receptor, Is Robustly Expressed in the Upper Gastrointestinal Tract and Modulated by Mucosal Inflammation 英文参考文献.docVIP

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Fc-Epsilon-RI, the High Affinity IgE-Receptor, Is Robustly Expressed in the Upper Gastrointestinal Tract and Modulated by Mucosal Inflammation 英文参考文献.doc

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Fc-Epsilon-RI, the High Affinity IgE-Receptor, Is Robustly Expressed in the Upper Gastrointestinal Tract and Modulated by Mucosal Inflammation 英文参考文献

Fc-Epsilon-RI,theHighAffinityIgE-Receptor,IsRobustly ExpressedintheUpperGastrointestinalTractand ModulatedbyMucosalInflammation ChristinaBannert1,BettinaBidmon-Fliegenschnee1,GeorgStary2,FlorianHotzy1,JudithStift3, SamuelNurko4,ZsoltSze′pfalusi1,EddaFiebiger4,EleonoraDehlink1,4* 1DepartmentofPaediatricsandAdolescentMedicine,MedicalUniversityofVienna,Vienna,Austria,2DepartmentofDermatology,DivisionofImmunology,Allergyand Infectious Diseases (DIAID), Medical University of Vienna, Vienna, Austria, 3Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria, 4Division of GastroenterologyandNutrition,Children’sHospitalBoston,HarvardMedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica Abstract Background:TheroleofthehighaffinityIgEreceptor,FceRI,inIgE-mediatedimmuneresponsesofthegastrointestinal(GI) mucosa is poorly understood. Currently, a detailed characterization of FceRI expression throughout the human gut is lacking.TheaimofthisstudywastodefinetheexpressionpatternofFceRIintheGItract. Methods/Principal Findings: We compared FceRI expression in children with gastritis/esophagitis (n=10), celiac disease (n=10),inflammatoryboweldisease(IBD)(n=9),andnormalmucosa(n=5).Thea–subunitofFceRI(FceRIa),detectedby immunohistochemistry,wasfoundoncellsinfiltratingthemucosaoftheesophagus,thestomach,andtheduodenum,but wasrarelydetectedinmoredistalsectionsoftheGItract.Accordingly,quantitativeRT-PCRanalysisonesophagus,stomach, duodenum,colon,andrectumbiopsiesrevealedthatFceRIaand-bexpressionlevelsdecreasedtowardsthedistalintestine. mRNAtranscriptsofthecommonFc-receptor-cchainwerepresentintheentireGImucosa.Double-immunofluorescence stainingofesophagealspecimensconfirmedthatFceRIawasexpressedonintraepithelialmastcellsandLangerhanscells. ThemRNAexpressionlevelsofthea,b,andcsubunitsofFceRIdidnotcorrelatewithtotalserumIgEbutwereassociated withmucosalinflammation. Conclusion/Significance:OurdatadefinetheupperGItractasthemainsiteforIgE-mediatedimmuneactivationviaFceRI